| Project/Area Number |
25850188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ニワトリ / 初期成長 / 摂食行動 / エネルギー代謝 / 脳 / 移植 / キメラ / 脳キメラ鶏 / 初期発育 / ミトコンドリア産生 / 熱産生 / 筋形成 |
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| Outline of Final Research Achievements |
The purpose of present study was to investigate the functional crosstalk energy homeostasis between brain and peripheral tissues in neonatal chicks. Specifically, we attempted to create brain chimera chickens using two type of commercial chicken (broiler and layer) which varied in early growth rate and energy metabolism. Brain graft technique revealed that the brain chimera chick exhibited reciprocal growth index, such as feed intake, body weight gain and tissue weight. Furthermore, expression of genes involved in hypothalamic carbohydrate metabolism, amino acid metabolism and immune response were also counter-regulated by brain grafting. These data suggest that brain graft technique is suitable for analysis of crosstalk between brain and peripheral energy metabolism in neonatal chicks.
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