Verification of ameliorating effect of lactic acid bacteria on atopic dermatitis based on the suppression of proinflammatory response of keratinocytes
| Project/Area Number |
25850190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 乳酸菌 / 皮膚角化細胞 / アトピー性皮膚炎 / ケモカイン / TARC / TLR2 |
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| Outline of Final Research Achievements |
This research aimed at evaluating the regulatory effect of lactobacillus strains on the proinflammatory responses in keratinocytes. Cell culture study showed that some Lactobacillus strains suppressed the expression of TARC (thymus and activation-regulated chemokine) in human keratinocyte cell line. Significant inhibitory effect on the development of dermatitis was observed by topical application of an extract obtained from disrupted bacterial body of the TARC-suppressive strain in atopic dermatitis model mice.
The study showed that a possibility of novel usage of a lactobacillus strains as a prevention material against the development of atopic dermatitis.
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Report
(4 results)
Research Products
(13 results)
