Toward the development of prognostic indicator and treatment strategy of mitral regurgitation focusing on atrial function

• Project/Area Number: 25850203
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Hokkaido University
• Principal Investigator: Nakamura Kensuke 北海道大学, 獣医学研究科, 助教 (80625898)
• Research Collaborator: OSUGA Tatsuyuki 北海道大学, 大学院獣医学研究科, 博士研究員
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 左心房 / 心機能 / 心エコー / 左心房機能 / ストレイン / 僧帽弁逆流 / 肺高血圧 / 心房機能 / 心エコー図検査 / 犬 / 慢性僧帽弁疾患

Outline of Final Research Achievements

In this study, 1) normal reactivity of left atrium to the volume overload, 2) normal reactivity of left atrium to cardiovascular drugs, 3) changes of left atrial function in cardiac disease, were evaluated. The left atrium has the potential capacity to become double reacting to volume overload and drugs. In the earlier coarse of cardiac disease, the left atrial function increases to adapt the worse condition. However, it decreases gradually with the progression of disease severity, and patients finally die when the worsening of atrial function cross over the certain limit. Left atrium may act as the last defense in animals with cardiac disease.

Research Products

• [Journal Article] Left Atrial Strain at Different Stages of Myxomatous Mitral Valve Disease in Dogs. (2017)
  • Author(s): Nakamura K, Kawamoto S, Osuga T, et al.
  • Journal Title: Journal of veterinary internal medicine Volume: 31 Issue: 2 Pages: 316-325
  • DOI: 10.1111/jvim.14660
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of experimental cardiac volume loading on left atrial phasic function in healthy dogs. (2016)
  • Author(s): Osuga T, Nakamura K, Morita T, et al.
  • Journal Title: American Journal of Veterinary Research Volume: 77 Issue: 9 Pages: 952-960
  • DOI: 10.2460/ajvr.77.9.952
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prognostic Value of Right Ventricular Tei Index in Dogs with Myxomatous Mitral Valvular Heart Disease. (2016)
  • Author(s): Nakamura K, Morita T, Osuga T, Morishita K, Sasaki N, Ohta H, Takiguchi M.
  • Journal Title: J Vet Intern Med Volume: 30 Issue: 1 Pages: 69-75
  • DOI: 10.1111/jvim.13820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vitamin D Status in Different Stages of Disease Severity in Dogs with Chronic Valvular Heart Disease (2015)
  • Author(s): Osuga T, Nakamura K, Morita T, Lim SY, Nisa K, Yokoyama N, Sasaki N, Morishita K, Ohta H, Takiguchi M.
  • Journal Title: J Vet Intern Med Volume: 29 Issue: 6 Pages: 1518-1523
  • DOI: 10.1111/jvim.13606
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of various cardiovascular drugs on indices obtained with two-dimensional speckle tracking echocardiography of the left atrium and time-left atrial area curve analysis in healthy dogs. (2015)
  • Author(s): Osuga T, Nakamura K, Morita T, Lim SY, Yokoyama N, Morishita K, Ohta H, Takiguchi M.
  • Journal Title: Am J Vet Res. Volume: 76 Issue: 8 Pages: 702-709
  • DOI: 10.2460/ajvr.76.8.702
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Quantitative contrast-enhanced ultrasonographic assessment of naturally occurring pancreatitis in dogs. (2015)
  • Author(s): Lim SY, Nakamura K, Morishita K, et al.
  • Journal Title: J Vet Intern Med Volume: 29 Issue: 1 Pages: 71-78
  • DOI: 10.1111/jvim.12470
  • Peer Reviewed / Open Access
• [Journal Article] Contrast-enhanced ultrasonographic findings in three dogs with pancreatic insulinoma. (2015)
  • Author(s): Nakamura K, Lim SY, Ochiai K, et al.
  • Journal Title: Vet Radiol Ultrasound Volume: 56 Issue: 1 Pages: 55-62
  • DOI: 10.1111/vru.12177
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Qualitative and quantitative contrast-enhanced ultrasonographic assessment of cerulein-induced acute pancreatitis in dogs. (2014)
  • Author(s): Lim SY, Nakamura K, Morishita K, Sasaki N, Murakami M, Osuga T, Ohta H, Yamasaki M, Takiguchi M
  • Journal Title: Journal of Veterinary Internal Medicine Volume: 28 Issue: 2 Pages: 496-503
  • DOI: 10.1111/jvim.12319
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of left atrial function in dogs with chronic mitral valvular heart disease. (2014)
  • Author(s): Kensuke Nakamura, Tatsuyuki Osuga, Keitaro Morishita, Shuji Suzuki, Tomoya Morita, Nozomu Yokoyama, Hiroshi Ohta, Masahiro Yamasaki, Mitsuyoshi Takiguchi
  • Journal Title: Journal of Veterinary Internal Medicine Volume: 28 Issue: 6 Pages: 1746-1752
  • DOI: 10.1111/jvim.12441
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease. (2014)
  • Author(s): Ohta H, Sunden Y, Yokoyama N, Nakamura K, et al,
  • Journal Title: Am J Vet Res Volume: 75 Issue: 8 Pages: 746-751
  • DOI: 10.2460/ajvr.75.8.746
  • Peer Reviewed
• [Journal Article] Hypercalcemia in a dog with chronic ingestion of maxacalcitol ointment. (2014)
  • Author(s): Nakamura, K., Tohyama, N., Yamasaki, M., Ohta, H., Morishita, K., and Takiguchi, M.
  • Journal Title: J. Am. Anim. Hosp. Assoc. Volume: 未定
  • Peer Reviewed
• [Journal Article] Contrast-enhanced Ultrasonographic Findings in Three Canine Patients Diagnosed with Pancreatic Insulinoma. (2014)
  • Author(s): Nakamura, K., Lim, S. Y., Ochiai. K., Yamasaki, M., Ohta, H., Morishita, K., Takagi, S., and Takiguchi, M.
  • Journal Title: Vet. Radiol. Ultrasound Volume: 未定
  • Peer Reviewed
• [Journal Article] Repeatability and reproducibility of measurements obtained via two-dimensional speckle tracking echocardiography of the left atrium and time-left atrial area curve analysis in healthy dogs. (2013)
  • Author(s): Osuga T, Nakamura K, Lim SY, Tamura Y, Kumara WR, Murakami M, Sasaki N, Morishita K, Ohta H, Yamasaki M, Takiguchi M
  • Journal Title: American Journal of Veterinary Research Volume: 74 Issue: 6 Pages: 864-869
  • DOI: 10.2460/ajvr.74.6.864
  • Peer Reviewed
• [Journal Article] Qualitative and quantitative contrast enhanced ultrasonography of the pancreas using bolus injection and continuous infusion methods in normal dogs. (2013)
  • Author(s): Lim, S. Y., Nakamura, K., Morishita, K., Sasaki, N., Murakami, M., Osuga. T., Ohta, H., Yamasaki, M., and Takiguchi, M.
  • Journal Title: J. Vet. Med. Sci. Volume: 75 Pages: 1601-1607
  • NAID: 130003362277
  • Peer Reviewed
• [Journal Article] Markedly increased expression of interleukin-8 in the colorectal mucosa of inflammatory colorectal polyps in miniature dachshunds. (2013)
  • Author(s): Tamura Y, Ohta H, Torisu S, Yuki M, Yokoyama N, Murakami M, Lim SY, Osuga T, Morishita K, Nakamura K, Yamasaki M, Takiguchi M
  • Journal Title: Veterinary Immunology and Immunopathology Volume: 156 Issue: 1-2 Pages: 32-42
  • DOI: 10.1016/j.vetimm.2013.09.017
  • Peer Reviewed
• [Journal Article] Expression of CD4+ T cell cytokine genes in the colorectal mucosa of inflammatory colorectal polyps in miniature dachshunds. (2013)
  • Author(s): Ohta H, Takada K, Torisu S, Yuki M, Tamura Y, Yokoyama N, Osuga T, Lim SY, Murakami M, Sasaki N, Nakamura K, Yamasaki M, Takiguchi M
  • Journal Title: Veterinary Immunology and Immunopathology Volume: 155 Issue: 4 Pages: 259-263
  • DOI: 10.1016/j.vetimm.2013.07.006
  • Peer Reviewed
• [Presentation] 日本小動物獣医学会シンポジウム「超音波定量診断技術の最前線」新しい心エコー図指標を用いた心不全の予後評価 (2016)
  • Author(s): 中村健介
  • Organizer: 平成27年度日本獣医師会獣医学術学会年次大会
  • Place of Presentation: 秋田県秋田市「秋田アトリオン」
  • Year and Date: 2016-02-27
  • Invited
• [Presentation] 教育講演「心エコーで予後を評価する－犬の僧帽弁疾患の場合」 (2016)
  • Author(s): 中村健介
  • Organizer: 第12回日本獣医内科学アカデミー学術大会
  • Place of Presentation: 神奈川県横浜市「パシフィコ横浜」
  • Year and Date: 2016-02-20
  • Invited
• [Presentation] 教育講演「エコーを活用した病態生理から考える腹水の鑑別診断」 (2016)
  • Author(s): 中村健介
  • Organizer: 第12回日本獣医内科学アカデミー学術大会
  • Place of Presentation: 神奈川県横浜市「パシフィコ横浜」
  • Year and Date: 2016-02-19
  • Invited
• [Presentation] ランチョンセミナー「心エコーから考える薬の効き目」 (2015)
  • Author(s): 中村健介
  • Organizer: 第103回日本獣医循環器学会
  • Place of Presentation: 北海道札幌市「札幌コンベンションセンター」
  • Year and Date: 2015-12-19
  • Invited
• [Presentation] クイズで学ぶ胸部画像診断 (2015)
  • Author(s): 中村健介
  • Organizer: 第11回日本獣医内科学アカデミー
  • Place of Presentation: 横浜
  • Year and Date: 2015-02-22
  • Invited
• [Presentation] 心臓だけじゃもったいない！ドプラ法の真の実力 (2014)
  • Author(s): 中村健介
  • Organizer: 第35回動物臨床医学年次大会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-15
  • Invited
• [Presentation] 心エコー図検査による左心房機能解析の妥当性と有用性 (2014)
  • Author(s): 中村健介
  • Organizer: 第157回日本獣医学会
  • Place of Presentation: 札幌
  • Year and Date: 2014-09-12
  • Invited
• [Presentation] X線検査でわかること、超音波検査でわかること (2014)
  • Author(s): 中村健介
  • Organizer: 第55回日本獣医画像診断学会
  • Place of Presentation: 大宮
  • Year and Date: 2014-06-14
  • Invited
• [Presentation] PROGNOSTIC VALUE OF LEFT ATRIAL FUNCTION IN DOGS WITH CHRONIC MITRAL VALVULAR HEART DISEASE. (2014)
  • Author(s): K. Nakamura, T. Osuga, S. Suzuki, K. Morishita, H. Ohta, M. Yamasaki, M. Takiguchi.
  • Organizer: 2014 American college of veterinary internal medicine forum
  • Place of Presentation: Nashville, Tennessee, USA.
  • Year and Date: 2014-06-04 – 2014-06-07
• [Presentation] シンポジウム「肝臓腫瘍 肝臓超音波検査・ソナゾイド」
  • Author(s): 中村健介
  • Organizer: 第１０回日本獣医がん学会
  • Place of Presentation: ホテルニューオータニ大阪
  • Invited
• [Presentation] ワークショップ「肺高血圧の病態と診断・治療」
  • Author(s): 中村健介
  • Organizer: 第１０回日本獣医内科学アカデミー学術大会
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] 教育講演「クイズで学ぶ胸部画像診断」
  • Author(s): 中村健介
  • Organizer: 第１０回日本獣医内科学アカデミー学術大会
  • Place of Presentation: パシフィコ横浜
  • Invited