| Project/Area Number |
25850203
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
OSUGA Tatsuyuki 北海道大学, 大学院獣医学研究科, 博士研究員
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 左心房 / 心機能 / 心エコー / 左心房機能 / ストレイン / 僧帽弁逆流 / 肺高血圧 / 心房機能 / 心エコー図検査 / 犬 / 慢性僧帽弁疾患 |
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| Outline of Final Research Achievements |
In this study, 1) normal reactivity of left atrium to the volume overload, 2) normal reactivity of left atrium to cardiovascular drugs, 3) changes of left atrial function in cardiac disease, were evaluated. The left atrium has the potential capacity to become double reacting to volume overload and drugs. In the earlier coarse of cardiac disease, the left atrial function increases to adapt the worse condition. However, it decreases gradually with the progression of disease severity, and patients finally die when the worsening of atrial function cross over the certain limit. Left atrium may act as the last defense in animals with cardiac disease.
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