Research on canine thrombotic disease with focus on ADAMTS13 and VWF

Research Project

Project/Area Number	25850213
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Veterinary medical science
Research Institution	Nihon University
Principal Investigator	MARUYAMA Haruhiko 日本大学, 生物資源科学部, 講師 (60434106)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	ADAMTS13 / 犬 / 血栓 / 血栓症 / VWF
Outline of Final Research Achievements	The purpose of this study was to clarify plasma ADAMTS13 activity in dogs with tumor that is one of causes of thrombosis, and to establish an anti-canine ADAMTS13 monoclonal antibody for measuring canine plasma ADAMTS13 antigen. As results, the plasma ADAMTS13 activities in dogs with tumor were significantly higher than those in normal dogs. The established monoclonal antibody reacted with canine ADAMTS13, but also with another protein. Therefore, although some improvements of the monoclonal antibody could be required, these results might contribute to facilitate pathobiology of thrombosis in dog.

Report

(4 results)