Regulation of autophagy by APOBEC2 and its physiological roles in skeletal muscle
| Project/Area Number |
25850218
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Utsunomiya University |
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Principal Investigator |
SATO YUSUKE 宇都宮大学, 農学部, 助教 (50589520)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 骨格筋 / APOBEC2 / オートファジー / ミトコンドリア / 代謝 |
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| Outline of Final Research Achievements |
Autophagy is essential for maintaining muscle mass. Dysregulation of autophagy is known to cause myopathy and atrophy. In the present study, we investigated whether APOBEC2, a muscle specific AID/APOBEC deaminase family, deficiency promotes autophagy/mitophagy in skeletal muscle. We found that autophagy/mitophagy up-regulation and metabolic dysregulation in APOBEC2 deficient muscle. Further studies should be done to elucidate the regulatory mechanisms of APOBEC2 mediated autophagy and its molecular function in skeletal muscle.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Implication of anti-inflammatory macrophages in regenerative moto-neuritogenesis: promotion of myoblast migration and neural chemorepellent semaphorin 3A expression in injured muscle.2014
Author(s)
Sakaguchi S, Shono J, Suzuki T, Sawano S, Anderson JE, Do MK, Ohtsubo H, Mizunoya W, Sato Y, Nakamura M, Furuse M, Yamada K, Ikeuchi Y, Tatsumi R.
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Journal Title
International Journal of Biochemistry & Cell Biology
Volume: 54
Pages: 272-285
Related Report
Peer Reviewed
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[Journal Article] Thiobencarb Herbicide Reduces Growth, Photosynthetic Activity, and Amount of Rieske Iron-Sulfur Protein in the Diatom Thalassiosira pseudonana.2013
Author(s)
Shimasaki Y, Tsuyama M, Tasmin R, Qiu X, Shimizu M, Sato Y, Yamasaki Y, Kato-Unoki Y, Nukata A, Nakashima T, Ichinose H, Wariishi H, Honjo T, Oshima Y
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Journal Title
Journal of biochemical and molecular toxicology
Volume: 27
Issue: 9
Pages: 437-444
DOI
Related Report
Peer Reviewed
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