| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Autophagy is essential for maintaining muscle mass. Dysregulation of autophagy is known to cause myopathy and atrophy. In the present study, we investigated whether APOBEC2, a muscle specific AID/APOBEC deaminase family, deficiency promotes autophagy/mitophagy in skeletal muscle. We found that autophagy/mitophagy up-regulation and metabolic dysregulation in APOBEC2 deficient muscle. Further studies should be done to elucidate the regulatory mechanisms of APOBEC2 mediated autophagy and its molecular function in skeletal muscle.
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