Possible involvement of novel peptides, NMU- and NMS-related peptide, in the hypothalamic function
Project/Area Number |
25850221
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Integrative animal science
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Research Institution | Kyoto University |
Principal Investigator |
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Research Collaborator |
MURAKAMI Noboru
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 新規ホルモン / 生理作用 / 摂食行動 / 自律神経機能調節 / ニューロメジンU / ニューロメジンS / 自律神経機能 |
Outline of Final Research Achievements |
The aim of this study is to clarify the physiological functions of novel peptides, NMU- and NMS-related peptide (NU1 and NU2, respectively) in hypothalamus. The morphological analysis using autoradiography indicated the existence of specific binding sites for novel peptides in the rat brain. Intraventricular (ICV) administration of NU1 and NU2 increased the food intake. During the dark phase, ICV administration of these peptides increased the body temperature. In addition, ICV-injection of NU1 and NU2 affected the locomotor activity and the energy expenditure. These results suggest that NU1 and NU2 play important roles in the hypothalamus.
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Report
(5 results)
Research Products
(12 results)