| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of this study is to clarify the physiological functions of novel peptides, NMU- and NMS-related peptide (NU1 and NU2, respectively) in hypothalamus. The morphological analysis using autoradiography indicated the existence of specific binding sites for novel peptides in the rat brain. Intraventricular (ICV) administration of NU1 and NU2 increased the food intake. During the dark phase, ICV administration of these peptides increased the body temperature. In addition, ICV-injection of NU1 and NU2 affected the locomotor activity and the energy expenditure. These results suggest that NU1 and NU2 play important roles in the hypothalamus.
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