| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The side population (SP) cells, which are thought to have characteristic of somatic stem cells, were identified in the bovine endometrial epithelial cells by flow cytometric analysis. The microarray analysis demonstrated that the expression patterns of bovine endometrial SP cells were similar to those of human endometrial SP cells. Whereas, the culture of bovine endometrial SP cells did not differentiate into osteoblasts or adipocytes. The bovine endometrial SP cells transplanted subcutaneously into nude mice did not generate a cystic mass with endometrial structure. These results suggest that the bovine endometrium regeneration mechanisms during estrous cycle might be different from those of human in which endometrial stem cells contribute to the remodeling process.
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