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Identification of the gene responsible for the spherulocyte-lacking mutant in the silkworm, Bombyx mori

Research Project

Project/Area Number 25850228
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Insect science
Research InstitutionThe University of Tokyo

Principal Investigator

KIUCHI Takashi  東京大学, 農学生命科学研究科, 助教 (60622892)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsカイコ突然変異体 / 血球 / 小球細胞 / 分化系譜 / ゲノム編集 / 遺伝学 / 分子生物学
Outline of Final Research Achievements

Hemocytes of the silkworm, Bombyx mori, are classified into five subsets. It is believed that those functions are basically involved in immune system. However, the function and the origin of spherulocytes are completely unknown. To solve these mysteries, we use the silkworm mutant which lack spherulocyte.
We narrowed the responsible gene for the spherulocyte-lacking mutant by genetic strategy. A deletion in a candidate gene was identified in the mutant strain. We also developed the genetic engineering methods to introduce the mutation in a target gene. The function of the candidate gene in spherulocyte differentiation will be elucidated by the developed method. Furthermore, the artificial spherulocyte-lacking silkworm can reveal the function and origin of spherulocyte.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Remarks (2 results)

  • [Journal Article] Recent progress in genome engineering techniques in the silkworm, Bombyx mori.2014

    • Author(s)
      Takaaki Daimon, Takashi Kiuchi, and Yoko Takasu
    • Journal Title

      Develpment, Growth, and Differentiation

      Volume: 56 Issue: 1 Pages: 14-25

    • DOI

      10.1111/dgd.12096

    • NAID

      40019949214

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Remarks] 東京大学-昆虫遺伝研究室 公式ウェブサイト

    • URL

      http://papilio.ab.a.u-tokyo.ac.jp/igb/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学-昆虫遺伝研究室 公式ウェブサイト

    • URL

      http://papilio.ab.a.u-tokyo.ac.jp/igb/index.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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