| Project/Area Number |
25850243
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 普遍的分子パターン / 植物ウイルス / 細胞死 / 両親媒性ヘリックス |
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| Outline of Final Research Achievements |
In this study, we aimed to reveal a novel plant immune system induced by a virus-encoded molecular pattern. As a result, we found an elicitor of immune responses in the N-terminal region of helicase proteins encoded by a comovirus. In this region, there is a predicted amphipathic helix involved in virus replication. We showed that the amphipathic helix is required for the induction of immune responses. In addition, we revealed that the elicitor activity is tightly correlated with the membrane modification activity, which is essential for the role of the amphipathic helix in virus replication.
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