| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We developed a novel method to generate allylcopper species from an allenylanilide, which possesses both an allene moiety and an aniline moiety in one molecule. Cu(I) catalyst facilitates a generation of allylcopper species along with formation of indole structure. The generated allylcopper species can work as nucleophile to various carbonyl compounds including ketones.
The reaction proceeded in enantioselective manner by utilizing a chiral diphosphine ligand. Thus the reaction produced chiral 2-(2-hydroxyethyl)indoles efficiently, whose scaffold is difficult to construct by other means.
The developed method is unique in simultaneous construction of indole structure and elongation of carbon scaffold.
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