| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We developed a Bronsted acid-promoted arene-ynamide cyclization to construct the 3H-pyrrolo[2,3-c]quinolines. This methodology enabled facile access to marinoquinolines A and C and aplidiopsamine A.
Futhermore, we now develop the efficient medium ring heterocycles with ynamides catalyzed by a Bronsted Acid. We investigate to apply this methodology to the total synthesis of complex molecules for a medicinal chemistry.
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