Development of a Bronsted Acid-Promoted Ene-Ynamide Cyclization
| Project/Area Number |
25860006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMAOKA Yousuke 京都大学, 薬学研究科(研究院), 助教 (60624723)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 複素環合成 / 天然物合成 / イナミド / 抗マラリア薬 / 有機合成 / 中員環合成 / 抗マラリア活性 / 酸 / 複素環 / 生物活性物質 / 中員環 / キノリン |
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| Outline of Final Research Achievements |
We developed a Bronsted acid-promoted arene-ynamide cyclization to construct the 3H-pyrrolo[2,3-c]quinolines. This methodology enabled facile access to marinoquinolines A and C and aplidiopsamine A.
Futhermore, we now develop the efficient medium ring heterocycles with ynamides catalyzed by a Bronsted Acid. We investigate to apply this methodology to the total synthesis of complex molecules for a medicinal chemistry.
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Report
(3 results)
Research Products
(5 results)
