Development of asymmetric sequential reactions for molecular syntheses using Lewis base-chlorosilane complex as reactive species
| Project/Area Number |
25860008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 有機合成化学 / 有機分子触媒 / 不斉合成 / 薬学 / 多成分連結反応 / アルドール反応 / ホスフィンオキシド / ケイ素化合物 / 有機化学 / 合成化学 / プロセス化学 |
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| Outline of Final Research Achievements |
Hypervalent silicon complexes, which are formed from chiral Lewis bases and chlorosilanes, are chemical species bearing both electrophilic sites and nucleophilic sites, and facilitie various stereoselective transformations.
I developed asymmetric sequential reactions involving double aldol reaction and halo aldol reaction using the sequential formations of hypervalent silicon complexes in the reaction. Moreover, applying the asymmetric reactions to molecular syntheses involving (-)-ericanone and optically active pyranones or oxetanes, we demonstrated utilities of these reactions.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Helically Chiral Diene in Asymmetric Catalysis: C2-Symmetric (Z,Z)-2,3-Bis[1-(diphenylphosphinyl)ethylidene]tetralin as Highly Active Lewis-Base Organocatalyst2013
Author(s)
Ogasawara, M.; Kotani, S.; Nakajima, H.; Furusho, H.; Miyasaka, M.; Shimoda, Y.; Wu, W.-Y.; Sugiura, M.; Takahashi, T.; Nakajima, M.
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Journal Title
Angewandte Chemie International Edition
Volume: 52
Issue: 51
Pages: 13798-13802
DOI
Related Report
Peer Reviewed
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