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Development of photocontrollable peroxynitrite donor based on photoinduced electron transfer for biological application

Research Project

Project/Area Number 25860009
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Chemical pharmacy
Research InstitutionNagoya City University

Principal Investigator

IEDA Naoya  名古屋市立大学, 薬学研究科(研究院), 助教 (00642026)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsパーオキシナイトライト / 一酸化窒素 / 活性窒素種 / 光ケージド化合物 / ケミカルバイオロジー / ケージド化合物 / 光ケージド / 可視光 / 光誘起電子移動
Outline of Final Research Achievements

We had developed a visible-light-controllable peroxynitrite generator based on photoinduced electron transfer. We discovered that one of synthesized compounds in the process was worked as a visible light controllable NO donor, named as NOBL-1. NOBL-1 could release NO in response to blue light in cells, confirmed by using fluorogenic NO probe, DAR-4M, and fluorescence microscope. Finally, we successfully controlled vasodilation, one of the main functions of NO, of rat aorta ex vivo with NOBL-1 and blue light. This compound is expected to be a chemical tool for NO research and a candidate as a chemotherapeutic reagent. In the next, we will develop a visible-light-controllable peroxynitrite generator with knowledge acquired in this research.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] hotomanipulation of Vasodilation with a Blue-Light-Controllable Nitric Oxide Releaser2014

    • Author(s)
      Naoya Ieda, Hidehiko Nakagawa, et al.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 136 Issue: 19 Pages: 7085-7091

    • DOI

      10.1021/ja5020053

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 光レドックス反応を応用した可視光制御一酸化窒素発生剤の開発2014

    • Author(s)
      家田直弥、堀田祐志、木村和哲、川口充康、宮田直樹、中川秀彦
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-10 – 2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 青色光制御型一酸化窒素発生剤の開発とその生体応用2014

    • Author(s)
      家田直弥、堀田祐志、木村和哲、川口充康、宮田直樹、中川秀彦
    • Organizer
      2014年光化学討論会
    • Place of Presentation
      札幌
    • Year and Date
      2014-10-11 – 2014-10-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 青色光制御型 NO ドナーの開発と血管弛緩の光制御2014

    • Author(s)
      家田直弥、堀田祐志、木村和哲、川口充康、宮田直樹、中川秀彦
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 青色光で制御可能なNOドナーの合成とその機能評価2014

    • Author(s)
      家田直弥、堀田祐志、木村和哲、宮田直樹、中川秀彦
    • Organizer
      創薬懇話会2014 in 岐阜
    • Place of Presentation
      岐阜
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] N-Nitrosoaminophenol骨格を有する可視光制御型NOドナーの開発2014

    • Author(s)
      家田直弥、堀田祐志、木村和哲、宮田直樹、中川秀彦
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Photo-manipulation of vasodilation with a novel photo-controllable nitric oxide releaser based on N-nitrosoaminophenol2014

    • Author(s)
      Naoya Ieda, Yuji Hotta, Kazunori Kimura, Naoki Miyata, Hidehiko Nakagawa
    • Organizer
      Third International Conference on H2S Biology and Medicine
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-06-04 – 2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 青色光で制御可能なN-nitrosoaniline型NOドナーを用いた血管弛緩制御2014

    • Author(s)
      家田直弥、堀田祐志、木村和哲、宮田直樹、中川秀彦
    • Organizer
      第12回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-05-23 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Design and synthesis of a novel visible light controllable NO releaser applicable for living cells2014

    • Author(s)
      Naoya Ieda, Naoki Miyata, Hidehiko Nakagawa
    • Organizer
      SFRRI2014
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] N-Nitrosoaniline構造を有する可視光制御可能な NOドナーによる血管弛緩2014

    • Author(s)
      家田直弥、堀田祐志、木村和哲、宮田直樹、中川秀彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 可視光で制御可能な一酸化窒素発生剤の設計・合成と機能評価2013

    • Author(s)
      家田直弥、鈴木孝禎、宮田直樹、中川秀彦
    • Organizer
      第31回メディシナルケミストリーシンポジウム
    • Place of Presentation
      アステールプラザ(広島)
    • Related Report
      2013 Research-status Report
  • [Remarks] 名古屋市立大学大学院薬学研究科薬化学分野

    • URL

      http://www.phar.nagoya-cu.ac.jp/hp/ykg/Yakka/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋市立大学 大学院薬学研究科 薬化学分野

    • URL

      http://www.phar.nagoya-cu.ac.jp/hp/ykg/Yakka/

    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 青緑色光で制御可能な一酸化窒素供与化合物2013

    • Inventor(s)
      家田直弥、中川秀彦
    • Industrial Property Rights Holder
      家田直弥、中川秀彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-12
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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