Development of photocontrollable peroxynitrite donor based on photoinduced electron transfer for biological application
| Project/Area Number |
25860009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
IEDA Naoya 名古屋市立大学, 薬学研究科(研究院), 助教 (00642026)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | パーオキシナイトライト / 一酸化窒素 / 活性窒素種 / 光ケージド化合物 / ケミカルバイオロジー / ケージド化合物 / 光ケージド / 可視光 / 光誘起電子移動 |
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| Outline of Final Research Achievements |
We had developed a visible-light-controllable peroxynitrite generator based on photoinduced electron transfer. We discovered that one of synthesized compounds in the process was worked as a visible light controllable NO donor, named as NOBL-1. NOBL-1 could release NO in response to blue light in cells, confirmed by using fluorogenic NO probe, DAR-4M, and fluorescence microscope. Finally, we successfully controlled vasodilation, one of the main functions of NO, of rat aorta ex vivo with NOBL-1 and blue light. This compound is expected to be a chemical tool for NO research and a candidate as a chemotherapeutic reagent. In the next, we will develop a visible-light-controllable peroxynitrite generator with knowledge acquired in this research.
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Report
(3 results)
Research Products
(14 results)
