Structure-anticancer activity relationship study of natural product and its derivatives with a novel mechanism of action
| Project/Area Number |
25860015
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Phaeosphaeride A / 天然物の全合成 / 抗がん剤 / 構造活性相関 |
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| Outline of Final Research Achievements |
Phaeosphaeride A, a natural product isolated from an endophytic fungus in 2006, inhibits the STAT3-dependent signaling. Thus, this natural product is expected to be a seed compound for developing an anticancer chemotherapeutic agent.
In this study, first total synthesis of phaeosphaeride A was achieved, and its stereostructures including the relative and absolute configurations were established. Its enantiomer, diastereomer, and some artifacts were also prepared for the sturucture-activity relationship study.
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Report
(4 results)
Research Products
(23 results)
