Development of Metal-free crossand its application-coupling reaction
| Project/Area Number |
25860017
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
MORIMOTO KOJI 立命館大学, 総合科学技術研究機構, 助教 (10543952)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | クロスカップリング / ヨウ素 / 芳香族 / グリコシル化 / 酸化 / 超原子価ヨウ素 / カップリング / ビアリール |
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| Outline of Final Research Achievements |
The biaryls units including phenol are important structural motifs for a wide range of functional molecules such as bioactive natural products, liquid crystals, and ligands for transition metal catalysts. Therefore, the direct oxidative cross-coupling of C-H bonds of phenols is a significantly attractive and convenient straightforward route to the synthesis of biaryls by avoiding the pre-functionalization of the starting materials. I developed a broadly applicable organo iodine(III) induced oxidative cross-coupling reaction of phenols and anilines. I also developed an excellent glycosylation of 2-deoxy-2-phthalimido-1-thio-glycosides using a combination of phenyliodine bis(trifluoroacetate) (PIFA) and trifluoromethanesulfonic acid.The reaction proceeded under mild conditions without use of heavy metal oxidants.
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Report
(4 results)
Research Products
(34 results)
