| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
The biaryls units including phenol are important structural motifs for a wide range of functional molecules such as bioactive natural products, liquid crystals, and ligands for transition metal catalysts. Therefore, the direct oxidative cross-coupling of C-H bonds of phenols is a significantly attractive and convenient straightforward route to the synthesis of biaryls by avoiding the pre-functionalization of the starting materials. I developed a broadly applicable organo iodine(III) induced oxidative cross-coupling reaction of phenols and anilines. I also developed an excellent glycosylation of 2-deoxy-2-phthalimido-1-thio-glycosides using a combination of phenyliodine bis(trifluoroacetate) (PIFA) and trifluoromethanesulfonic acid.The reaction proceeded under mild conditions without use of heavy metal oxidants.
|
