| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
We have improved a sugar response of an artificial pancreas system based on a molecular necklace structure. Our previous system was composed of two materials. One was a bead-like molecule modified with a sugar sensor moiety, phenylboronic acid-modified γ-cyclodextrin (PBA-γ-CyD). The other was a chain polymer modified with naphthalene and insulin at each terminal, naphthalene-polyethylene glycol-insulin (Naph-PEG-Ins). The Naph-PEG-Ins/PBA-γ-CyD molecular necklace was poorly water soluble at pH 7.4; however, sugar addition induced disintegration of the molecular necklace, and the release rate of Naph-PEG-Ins was accelerated. In this study, the sugar sensor moiety was replaced by nitrophenylboronic acid (NPBA). The molecular necklace containing NPBA showed a better sugar response due to its stronger sugar affinity and its three-dimensional arrangement in the molecular necklace.
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