| Project/Area Number |
25860030
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
HAMA Susumu 京都薬科大学, 薬学部, 講師 (60438041)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腫瘍微小環境 / DDS / がん微小環境 / ナノDDS / 低pH / ドラッグデリバリー / 薬物放出 |
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| Outline of Final Research Achievements |
In anti-cancer therapy mediated by a liposome-based drug delivery system (DDS), overall efficacy depends on the release efficiency of anti-cancer drug from the liposomes after the delivery to tumor tissue. In this study, I developed liposomes incorporating peptide, which can alter the physicochemical property in response to tumoral acidic pH, for tumor-specific drug release. Therefore, I designed a slightly acidic pH-sensitive membrane perturbable peptide (SAMP), and constructed DDS by the incorporation of SAMP into liposomal membrane (SAMP-lipo). In the cells treated with SAMP-lipo co-encapsulating low- and high-molecular drug, SAMP-lipo could release only low-molecular drugs outside of cells and deliver only high-molecular drugs into cancer cells at slightly acidic pH. These results suggest that SAMP-lipo are a novel intelligent nanoparticle being capable of the effective and selective release of low-molecular drugs in response to tumoral acidic pH.
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