Design and Evaluation of Fullerene-fluorescence dye hybrid Nanoparticles for the Photosensitizer in Photodynamic Therapy
| Project/Area Number |
25860034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | フラーレン / がん光線力学療法 / ナノ粒子 / 活性酸素種 / 光増感剤 / 蛍光色素 / フラーレンC60 / シクロデキストリン |
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| Outline of Final Research Achievements |
The fullerene family especially C60, is generally regarded as an efficient photosensitizer for PDT due to light absorption at relatively long wavelengths and the high quantum yield of photoexcitation reactions.In this study, we evaluated the photosensitizing ability of C60/HP-β-CyD nanoparticles under visible light irradiation as a new photosensitizer in PDT. The photodynamic activity of C60/HP-β-CyD nanoparticles was studied in detail by in vitro and in vivo experiments. In addition, we revealed that C60-fluorescence dye hybrid nanoparticle is able to produce reactive oxygen species by the light irradiation at the wavelength that belongs to the fluorescence dye.
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Report
(3 results)
Research Products
(22 results)
