Roles of chondroitin sulfate interacting with RAGE involved in tumor and Alzheimer's disease
Project/Area Number |
25860037
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | Meijo University |
Principal Investigator |
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Research Collaborator |
SUGAHARA KAZUYUKI 北海道大学, 大学院先端生命科学研究院, 名誉教授 (60154449)
YAMADA SHUHEI 名城大学, 薬学部, 教授 (70240017)
IKEGAWA SHIRO 理化学研究所, 骨関節疾患研究チーム, 主任研究員 (30272496)
MATSUMOTO NAOMICHI 横浜市立大学, 医学研究科, 教授 (80325638)
MIYAKE NORIKO 横浜市立大学, 医学研究科, 准教授 (40523494)
KOSHO TOMOKI 信州大学, 医学部附属病院, 准教授 (90276311)
Janecke Andreas Innsbruck Medical University
Nürnberg Peter University of Cologne
Kennerknecht Ingo Institute of Human Genetics, Westfälische Wilhelms, Universität
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | コンドロイチン硫酸 / RAGE / 癌 / アルツハイマー病 / プロテオグリカン / ヘパラン硫酸 / 骨・皮膚疾患 / 老化 / てんかん / 糖尿病 / デルマタン硫酸 |
Outline of Final Research Achievements |
To understand the roles of chondroitin sulfate and Receptor for Advanced Glycation-End product (RAGE) in tumor metastasis, RAGE-knockout mice were utilized for the analysis. We revealed that RAGE and chondroitin sulfate are involved in tumor metastasis and neuritogenesis based on the analyses of RAGE-knockout mice. We developed the production of recombinant RAGE using Pichia pastoris. Furthermore, we have identified a patient with short stature and bone dysplasia caused by mutation in the genes encoding chondroitin sulfate-biosynthetic glycosyltransferase.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor.2015
Author(s)
Marina Koutsioumpa, Evangelia Poimenidi, Evangelia Pantazaka, Christina Theodoropoulou, Angeliki Skoura, Vasileios Megalooikonomou, Nelly Kieffer, Jose Courty, Shuji Mizumoto, Kazuyuki Sugahara, and Evangelia Papadimitriou.
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Journal Title
Molecular Cancer
Volume: 14
Issue: 1
Pages: 19-19
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3.2015
Author(s)
Birgit S. Budde, Shuji Mizumoto, Ryo Kogawa, Christian Becker, Janine Altmuller, Holger Thiele, Franz Ruschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hammerle, Wolffang Hohne, Kazuyuki Sugahara, Peter Nurnberg, Ingo Kennerknecht.
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Journal Title
Human Genetics
Volume: in press
Issue: 7
Pages: 691-704
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome2013
Author(s)
Thomas Muller, Shuji Mizumoto, Indrajit Suresh, Yoshie Komatsu, Julia Vodopiutz, Munis Dundar, Volker Straub, Arno Lingenhel, Andreas Melmer, Silvia Lechner, Johannes Zschocke, Kazuyuki Sugahara, Andreas R Janecke
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Journal Title
Human Molecular Genetics
Volume: 22
Issue: 18
Pages: 3761-3772
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical and radiographic features of the autosomal recessive form of brachyolmia caused by PAPSS2 mutations2013
Author(s)
Aritoshi Iida*, Pelin Ozlem Simsek-Kiper*, Shuji Mizumoto*, Touma Hoshino, Nursel Elcioglu, Eva Horemuzova, Stefan Geiberger, Gozde Yesil, Hulya Kayserili, Gulen Eda Unite, Koray Boduroglu, Shigehiko Watanabe, Hirofumi Ohashi, Yasemin Alanay, Kazuyuki Sugahara, Gen Nishimura, Shiro Ikegawa (*equal contribution)
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Journal Title
Human Mutation
Volume: 34
Issue: 10
Pages: 1381-1386
DOI
Related Report
Peer Reviewed
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[Presentation] グリコサミノグリカンの生合成に関わるグルクロン酸転移酵素-Iの変異によるインドネシアのニアス島で見つかった骨疾患2015
Author(s)
◯Shuji Mizumoto, Birgit S. Budde, Ryo Kogawa, Christian Becker, Janine Altmuller, Holger Thiele, Franz Ruschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hammerle, Wolffang Hohne, Kazuyuki Sugahara, Peter Nurnberg, Ingo Kennerknecht
Organizer
第38回日本分子生物学会年会・第88回日本生化学会大会・合同大会
Place of Presentation
神戸ポートアイランド(神戸)
Year and Date
2015-12-01
Related Report
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[Presentation] Loss-of-function mutation of glucuronyltransferase-I causes skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia2015
Author(s)
◯Shuji Mizumoto, Birgit S. Budde, Ryo Kogawa, Christian Becker, Janine Altmuller, Holger Thiele, Franz Ruschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hammerle, Wolffang Hahne, Kazuyuki Sugahara, Peter Nurnberg, Ingo Kennerknecht
Organizer
9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium
Place of Presentation
Ewha Womans University (Seoul, Korea)
Year and Date
2015-08-24
Related Report
Int'l Joint Research
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[Presentation] グリコサミノグリカンの生合成に関わるグルクロン酸転移酵素-Iの新規変異による骨疾患の糖鎖生物学的研究2015
Author(s)
○水本秀二, Birgit S. Budde, 古川諒, Christian Becker, Janine Altmuller, Holger Thiele, Franz Ruschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hammerle, Wolffang Hohne, 菅原一幸, Peter Nurnberg, Ingo Kennerknecht
Organizer
第34回日本糖質学会年会
Place of Presentation
東京大学(東京)
Year and Date
2015-07-31
Related Report
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[Presentation] コンドロイチン・デルマタン・ヘパラン硫酸の生合成に関わるグルクロン酸転移酵素-Iの変異(P140L)による骨疾患の糖鎖生物学的研究2015
Author(s)
○水本秀二, Birgit S. Budde, 古川諒, Christian Becker, Janine Altmuller, Holger Thiele, Franz Ruschendorf, Mohammad R. Toliat, Gerrit Kaleschke, Johannes M. Hammerle, Wolffang Hohne, 菅原一幸, Peter Nurnberg, Ingo Kennerknecht
Organizer
第79回日本生化学会中部支部例会
Place of Presentation
信州大学松本キャンパス(松本)
Year and Date
2015-05-23
Related Report
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[Presentation] Spondyloepimetaphyseal dysplasia and Ehlers-Danlos syndrome caused by mutations of glycosaminoglycan biosynthetic enzymes, GalT-II and DS-epimerase2014
Author(s)
Shuji Mizumoto, Masahiro Nakajima, Thomas Muller Noriko Miyake, Ryo Kogawa, Yoshie Komatsu, Naomichi Matsumoto, Andreas R Janecke, Shiro Ikegawa, Kazuyuki Sugahara
Organizer
Joint Meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research
Place of Presentation
Hilton Hotel (Hawaii, USA)
Year and Date
2014-11-19
Related Report
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[Presentation] PAPS合成酵素2の変異は常染色体劣性型短脊柱症を引き起こす2014
Author(s)
水本秀二, 飯田有俊, Pelin Ozlem Simsek-Kiper, 星野冬馬, Nursel Elcioglu, Eva Horemuzova, Stefan Geiberger, Gozde Yesil, Hulya Kayserili, Gulen Eda Utine, Koray Boduroglu, 渡邉成彦, 大橋博文, Yasemin Alanay, 西村玄, 池川志郎, 菅原一幸
Organizer
第33回日本糖質学会年会
Place of Presentation
名古屋大学(名古屋)
Year and Date
2014-08-11
Related Report
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[Presentation] コンドロイチン硫酸/デルマタン硫酸の生合成に関わる酵素の変異による骨・皮膚疾患の糖鎖生物学的研究
Author(s)
○水本秀二, 中島正宏, Thomas Muller, 三宅紀子, Indrajit Suresh, 古川諒, 小松由枝, 松本直通, Andreas R Janecke, 池川志郎, 菅原一幸
Organizer
日本生化学会北海道支部 支部例会第50回記念大会
Place of Presentation
北海道大学医学部(札幌)
Related Report
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[Presentation] グリコサミノグリカンの生合成に関わる酵素の新規変異による脊椎骨端骨幹端異形成症とエーラス・ダンロス症候群の糖鎖生物学的研究
Author(s)
○水本秀二, 中島正宏, Thomas Muller, 三宅紀子, Indrajit Suresh, 古川諒, 小松由枝, 松本直通, Andreas R Janecke, 池川志郎, 菅原一幸
Organizer
第32回日本糖質学会年会
Place of Presentation
大阪国際交流センター(大阪)
Related Report
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[Presentation] PAPS合成酵素2の変異によって引き起こされる常染色体劣性型短脊柱症
Author(s)
○水本秀二, 飯田有俊, Pelin Ozlem Simsek-Kiper, 星野冬馬, Nursel Elcioglu, Eva Horemuzova, Stefan Geiberger, Gozde Yesil, Hulya Kayserili, Gulen Eda Utine, Koray Boduroglu, 渡邉成彦, 大橋博文, Yasemin Alanay, 西村玄, 池川志郎, 菅原一幸
Organizer
日本薬学会第134回年会
Place of Presentation
熊本大学工学部(熊本)
Related Report
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