Target of lysophosphatidylserine on mast cells

Research Project

Project/Area Number	25860041
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Biological pharmacy
Research Institution	Tohoku University
Principal Investigator	MAKIDE Kumiko 東北大学, 薬学研究科(研究院), 助教 (30519773)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	リゾリン脂質 / マスト細胞 / 脂質メディエーター / 受容体 / カルシウムチャネル
Outline of Final Research Achievements	It is well known that lysophosphatidylserine (LysoPS) has stimulating activity on mast cells. Although several studies suggested the presence of specific target for LysoPS on mast cells, the molecule remains to be identified. In this study, we analysed the responses of TRP channels to LysoPS and found that TPRV1 responds to LysoPS.

Report

(3 results)