Target of lysophosphatidylserine on mast cells
| Project/Area Number |
25860041
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
MAKIDE Kumiko 東北大学, 薬学研究科(研究院), 助教 (30519773)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | リゾリン脂質 / マスト細胞 / 脂質メディエーター / 受容体 / カルシウムチャネル |
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| Outline of Final Research Achievements |
It is well known that lysophosphatidylserine (LysoPS) has stimulating activity on mast cells. Although several studies suggested the presence of specific target for LysoPS on mast cells, the molecule remains to be identified. In this study, we analysed the responses of TRP channels to LysoPS and found that TPRV1 responds to LysoPS.
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Report
(3 results)
Research Products
(2 results)
