Regulation of intercellular crosstalk by induced ubiquitin ligase SSB
Project/Area Number |
25860043
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | Nagoya University |
Principal Investigator |
FUMIHIKO Okumura 名古屋大学, 理学(系)研究科(研究院), 助教 (00507212)
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Co-Investigator(Renkei-kenkyūsha) |
嘉村 巧 (40333455)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | ユビキチン / ガン / タンパク質分解 |
Outline of Final Research Achievements |
The aim is to identify the molecular mechanism which regulates intercellular crosstalk by SOCS box protein SSB. We identified SSB-binding proteins. Given that SSB is a ubiquitin ligase, we checked the stability of SSB-binding proteins and found that one of the candidate accumulated by knockdown of SSB. The candidate has been reported as a tumor suppressor gene and also as a oncogene. We are currently studying the physiological function of the candidate protein.
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Report
(3 results)
Research Products
(4 results)
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[Presentation] pVHLはFOBとHIF-αの分解を介してVHL病を制御する2014
Author(s)
1.奥村 文彦, 植松 桂司, 松崎 真理子, 平野 みえ, 奥村 晶子, 錦見 昭彦, 金森 正和, 執印 太郎, 福井 宣規, 中務 邦雄, 嘉村 巧
Organizer
第37回 日本分子生物学会年会
Place of Presentation
横浜
Year and Date
2014-11-26
Related Report
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