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A novel secretory protein neudesin as a target for anti-obesity drug

Research Project

Project/Area Number 25860045
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionKobe Pharmaceutical University (2015)
Kyoto University (2013-2014)

Principal Investigator

Ohta Hiroya  神戸薬科大学, 薬学部, 研究員 (40638988)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsneudesin / 肥満 / エネルギー消費 / 交感神経系 / 分泌性因子 / 交感神経系の活性化 / エネルギー消費の亢進 / 交感神経の活性化 / 脂肪酸酸化の亢進 / Neudesin / 脂肪組織 / 副腎
Outline of Final Research Achievements

We tried to elucidate the physiological roles of Neudesin, a secretory protein, using Neudesin KO mice. We showed that Neudesin KO mice were resistant to high-fat diet induced obesity. Food intake and absorption of fat were comparable between WT and Neudesin KO mice. However, Neudesin KO mice showed increased energy expenditure caused by enhanced sympathetic nervous activity. These results suggest that Neudesin play roles in the development of obesity, and neudesin might be a novel target for anti-obesity drug.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Invited: 1 results)

  • [Journal Article] Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy.2015

    • Author(s)
      Itoh N, Ohta H, Konishi M.
    • Journal Title

      Frontier Endocrinology (Lausanne).

      Volume: 6 Pages: 1-9

    • DOI

      10.3389/fendo.2015.00154

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis2015

    • Author(s)
      Ohta H, Kimura I, Konishi M, Itoh N
    • Journal Title

      frontiers in Molecular Biosciences

      Volume: 2 Pages: 24-24

    • DOI

      10.3389/fmolb.2015.00024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Deletion of Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity2015

    • Author(s)
      Hiroya Ohta, Morichika Konishi, Yusuke Kobayashi, Atsuki Kashio, Takayuki Mochiyama, Shigenobu Matsumura, Kazuo Inoue, Tohru Fushiki, Kazuwa Nakao, Ikuo Kimura, Nobuyuki Itoh
    • Journal Title

      Scientific Reports

      Volume: 印刷中 Issue: 1 Pages: 10049-10049

    • DOI

      10.1038/srep10049

    • NAID

      120005753823

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of Fgf23 in Activated Dendritic Cells and Macrophages in Response to Immunological Stimuli in Mice2015

    • Author(s)
      Yuki Masuda, Hiroya Ohta, Yumiko Morita, Yoshiaki Nakayama, Ayumi Miyake, Nobuyuki Itoh, Morichika Konishi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 5 Pages: 687-693

    • DOI

      10.1248/bpb.b14-00276

    • NAID

      130005068085

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fgf signaling in adipocytes as a target for metabolic diseases2013

    • Author(s)
      H. Ohta, N. Itoh
    • Journal Title

      Molecular Metabolism

      Volume: 2 Issue: 1 Pages: 3-4

    • DOI

      10.1016/j.molmet.2012.11.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet2013

    • Author(s)
      Y. Murata, K. Nishio, T. Mochiyama, M. Konishi, M. Shimada, H. Ohta, N. Itoh
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 7 Pages: 1-7

    • DOI

      10.1371/journal.pone.0069330

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16.2013

    • Author(s)
      Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N.
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 7 Pages: 544-553

    • DOI

      10.1111/gtc.12055

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 分泌性因子neudesinの遺伝子欠損マウスは交感神経活性の亢進により食餌誘導性肥満に耐性を示す2015

    • Author(s)
      太田紘也, 小西守周, 橋本大嗣, 樫尾篤樹, 持山喬之, 松村成暢, 井上和生, 伏木亨, 中山喜明, 中尾一和, 木村郁夫, 伊藤信行
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満に関わる分泌性因子neudesinの同定と解析2015

    • Author(s)
      太田紘也, 小西守周, 松村成暢, 井上和生, 伏木亨, 中尾一和, 木村郁夫, 伊藤信行
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 神経栄養因子neudesinの遺伝子欠損マウスは高脂肪食誘導性肥満に耐性を示した2015

    • Author(s)
      太田紘也, 小西守周, 松村成暢, 井上和生, 伏木亨, 中尾一和, 木村郁夫, 伊藤信行
    • Organizer
      第20回アディポサイエンス・シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分泌性因子neudesinの遺伝子欠損マウスは、交感活性の亢進により食餌誘導性肥満に耐性を示す2014

    • Author(s)
      持山 喬之, 太田 紘也, 小西 守周, 樫尾 篤樹, 小林 祐介,松村 成暢, 井上 和生, 伏木 亨, 中尾 一和, 木村 郁夫, 伊藤 信行
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 分泌性因子Neudesinの遺伝子欠損マウスは食餌誘導性肥満に耐性を示す2014

    • Author(s)
      太田 紘也, 樫尾 篤樹, 小西 守周, 木村 郁夫, 持山 喬之, 松村 成暢, 井上 和生, 伏木 亨, 伊藤 信行
    • Organizer
      第19回アディポサイエンス・シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 分泌性因子Neudesinの遺伝子欠損マウスは食餌誘導性肥満に耐性を示す

    • Author(s)
      太田紘也、小林祐介、小西守周、樫尾篤樹、松村成暢、井上和生、伏木亨、伊藤信行
    • Organizer
      第18回アディポサイエンス・シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規分泌性因子Neudesin の遺伝子欠損マウスは食餌誘導性肥満に耐性を示す

    • Author(s)
      樫尾 篤樹、太田 紘也、小林 祐介、杉村 絵理、小西 守周、木村 郁夫、松村 成暢、井上 和生、伏木 亨、伊藤 信行
    • Organizer
      第36回分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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