A novel secretory protein neudesin as a target for anti-obesity drug

• Project/Area Number: 25860045
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Kobe Pharmaceutical University (2015); Kyoto University (2013-2014)
• Principal Investigator: Ohta Hiroya 神戸薬科大学, 薬学部, 研究員 (40638988)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: neudesin / 肥満 / エネルギー消費 / 交感神経系 / 分泌性因子 / 交感神経系の活性化 / エネルギー消費の亢進 / 交感神経の活性化 / 脂肪酸酸化の亢進 / Neudesin / 脂肪組織 / 副腎

Outline of Final Research Achievements

We tried to elucidate the physiological roles of Neudesin, a secretory protein, using Neudesin KO mice. We showed that Neudesin KO mice were resistant to high-fat diet induced obesity. Food intake and absorption of fat were comparable between WT and Neudesin KO mice. However, Neudesin KO mice showed increased energy expenditure caused by enhanced sympathetic nervous activity. These results suggest that Neudesin play roles in the development of obesity, and neudesin might be a novel target for anti-obesity drug.

Research Products

• [Journal Article] Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy. (2015)
  • Author(s): Itoh N, Ohta H, Konishi M.
  • Journal Title: Frontier Endocrinology (Lausanne). Volume: 6 Pages: 1-9
  • DOI: 10.3389/fendo.2015.00154
  • Peer Reviewed / Open Access
• [Journal Article] Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis (2015)
  • Author(s): Ohta H, Kimura I, Konishi M, Itoh N
  • Journal Title: frontiers in Molecular Biosciences Volume: 2 Pages: 24-24
  • DOI: 10.3389/fmolb.2015.00024
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Deletion of Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity (2015)
  • Author(s): Hiroya Ohta, Morichika Konishi, Yusuke Kobayashi, Atsuki Kashio, Takayuki Mochiyama, Shigenobu Matsumura, Kazuo Inoue, Tohru Fushiki, Kazuwa Nakao, Ikuo Kimura, Nobuyuki Itoh
  • Journal Title: Scientific Reports Volume: 印刷中 Issue: 1 Pages: 10049-10049
  • DOI: 10.1038/srep10049
  • NAID: 120005753823
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of Fgf23 in Activated Dendritic Cells and Macrophages in Response to Immunological Stimuli in Mice (2015)
  • Author(s): Yuki Masuda, Hiroya Ohta, Yumiko Morita, Yoshiaki Nakayama, Ayumi Miyake, Nobuyuki Itoh, Morichika Konishi
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 38 Issue: 5 Pages: 687-693
  • DOI: 10.1248/bpb.b14-00276
  • NAID: 130005068085
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Fgf signaling in adipocytes as a target for metabolic diseases (2013)
  • Author(s): H. Ohta, N. Itoh
  • Journal Title: Molecular Metabolism Volume: 2 Issue: 1 Pages: 3-4
  • DOI: 10.1016/j.molmet.2012.11.004
  • Peer Reviewed
• [Journal Article] Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet (2013)
  • Author(s): Y. Murata, K. Nishio, T. Mochiyama, M. Konishi, M. Shimada, H. Ohta, N. Itoh
  • Journal Title: PLOS ONE Volume: 8 Issue: 7 Pages: 1-7
  • DOI: 10.1371/journal.pone.0069330
  • Peer Reviewed
• [Journal Article] Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16. (2013)
  • Author(s): Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N.
  • Journal Title: Genes Cells Volume: 18 Issue: 7 Pages: 544-553
  • DOI: 10.1111/gtc.12055
  • Peer Reviewed
• [Presentation] 分泌性因子neudesinの遺伝子欠損マウスは交感神経活性の亢進により食餌誘導性肥満に耐性を示す (2015)
  • Author(s): 太田紘也, 小西守周, 橋本大嗣, 樫尾篤樹, 持山喬之, 松村成暢, 井上和生, 伏木亨, 中山喜明, 中尾一和, 木村郁夫, 伊藤信行
  • Organizer: 第38回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-03
• [Presentation] 肥満に関わる分泌性因子neudesinの同定と解析 (2015)
  • Author(s): 太田紘也, 小西守周, 松村成暢, 井上和生, 伏木亨, 中尾一和, 木村郁夫, 伊藤信行
  • Organizer: 第70回日本体力医学会大会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-09-19
  • Invited
• [Presentation] 神経栄養因子neudesinの遺伝子欠損マウスは高脂肪食誘導性肥満に耐性を示した (2015)
  • Author(s): 太田紘也, 小西守周, 松村成暢, 井上和生, 伏木亨, 中尾一和, 木村郁夫, 伊藤信行
  • Organizer: 第20回アディポサイエンス・シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2015-08-22
• [Presentation] 分泌性因子neudesinの遺伝子欠損マウスは、交感活性の亢進により食餌誘導性肥満に耐性を示す (2014)
  • Author(s): 持山 喬之, 太田 紘也, 小西 守周, 樫尾 篤樹, 小林 祐介,松村 成暢, 井上 和生, 伏木 亨, 中尾 一和, 木村 郁夫, 伊藤 信行
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-25
• [Presentation] 分泌性因子Neudesinの遺伝子欠損マウスは食餌誘導性肥満に耐性を示す (2014)
  • Author(s): 太田 紘也, 樫尾 篤樹, 小西 守周, 木村 郁夫, 持山 喬之, 松村 成暢, 井上 和生, 伏木 亨, 伊藤 信行
  • Organizer: 第19回アディポサイエンス・シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-23
• [Presentation] 分泌性因子Neudesinの遺伝子欠損マウスは食餌誘導性肥満に耐性を示す
  • Author(s): 太田紘也、小林祐介、小西守周、樫尾篤樹、松村成暢、井上和生、伏木亨、伊藤信行
  • Organizer: 第18回アディポサイエンス・シンポジウム
  • Place of Presentation: 大阪
• [Presentation] 新規分泌性因子Neudesin の遺伝子欠損マウスは食餌誘導性肥満に耐性を示す
  • Author(s): 樫尾 篤樹、太田 紘也、小林 祐介、杉村 絵理、小西 守周、木村 郁夫、松村 成暢、井上 和生、伏木 亨、伊藤 信行
  • Organizer: 第36回分子生物学会年会
  • Place of Presentation: 神戸