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Regulation of primary cilia formation cycle by Kif24

Research Project

Project/Area Number 25860048
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionNara Institute of Science and Technology

Principal Investigator

KOBAYASHI Tetsuo  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (80433994)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords一次繊毛 / 中心小体
Outline of Final Research Achievements

Primary cilia function as cell’s antenna and malfunction of this organelle causes various diseases called ciliopathy. Once cells exit cell cycle and go to quiescent phase, a primary cilium is formed. On the other hand, the primary cilium disappears when cells reenter to cell cycle. However, molecular mechanisms underlying assembly and disappearance of primary cilia are unclear. Here, we identified Talpid3 to associate with centriolar proteins CP110 and Kif24, requisite proteins for regulation of primary ciliogenesis. We showed that Talpid3 and Cep290, a causal protein of ciliopathies, play an essential role in early stage of primary ciliogenesis by controlling ciliary vesicle formation.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly2014

    • Author(s)
      Tetsuo Kobayashi, Sehyun Kim, Yu-Chun Lin, Takanari Inoue, Brian David Dynlacht
    • Journal Title

      Journal of Cell Biology

      Volume: 204 Issue: 2 Pages: 215-229

    • DOI

      10.1083/jcb.201304153

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] HDAC2 mediates loss of primary cilia in pancreatic ductal adenocarcinoma cells2014

    • Author(s)
      Tetsuo Kobayashi, Kosuke Nakazono, Mio Tokuda, Brian David Dynlacht, Hiroshi Itoh
    • Organizer
      The 2014 ASCB/IFCB Meeting
    • Place of Presentation
      Philadelphia convention center, Philadelphia, Pennsylvania, USA
    • Year and Date
      2014-12-06 – 2014-12-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 一次繊毛におけるRab-like ファミリータンパク質群の機能解析2014

    • Author(s)
      太田 麗央、小林 哲夫、伊東 広
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 膵管癌細胞における一次繊毛消失機構の解析2014

    • Author(s)
      中薗 昂亮、小林 哲夫、徳田 澪、Brian David Dynlacht、伊東 広
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 膵管癌細胞における一次繊毛消失機構の解析2014

    • Author(s)
      小林 哲夫、中薗 昂亮、Brian David Dynlacht、伊東 広
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良県新公会堂、奈良県奈良市
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular mechanism of loss of primary cilia in pancreatic ductal adenocarcinoma cells2014

    • Author(s)
      Tetsuo Kobayashi, Kosuke Nakazono, Izumi Dateyama, Brian David Dynlacht, Hiroshi Itoh
    • Organizer
      Keystone Symposia -Cilia, Development and Human Disease-
    • Place of Presentation
      Granlibakken Resort, Tahoe city, CA, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] CP110-interacting proteins, Talpid3 and Cep290, play distinct roles in cilia assembly2013

    • Author(s)
      Tetsuo Kobayashi, Sehyun Kim, Yu-Chun Lin, Takanari Inoue, Brian David Dynlacht
    • Organizer
      第65回日本細胞生物学大会
    • Place of Presentation
      ウインクあいち、愛知県名古屋市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 膵管癌細胞における一次繊毛消失メカニズムの解析2013

    • Author(s)
      小林 哲夫、中薗 昂亮、Brian David Dynlacht、伊東 広
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド、兵庫県神戸市
    • Related Report
      2013 Research-status Report
  • [Remarks] 奈良先端科学技術大学院大学バイオサイエンス研究科分子情報薬理学研究室ホームページ

    • URL

      http://bsw3.naist.jp/itoh/?cate=244&id=458

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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