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Study on the role of protein arginine methyltransferase 5 in cardiac hypertrophy

Research Project

Project/Area Number 25860052
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

Katanasaka Yasufumi  静岡県立大学, 薬学部, 講師 (00583973)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords心肥大 / 心不全 / アルギニンメチル化酵素 / 転写 / PRMT5 / MEP50 / p300/GATA4転写経路 / GATA4 / p300 / メチルトランスフェラーゼ
Outline of Final Research Achievements

Heart failure is one of the leading causes of death in industrialized countries, and cardiac hypertrophy is a risk factor for heart failure. We have demonstrated that PRMT5, a protein arginine methyltransferase, is involved in the promotion of cardiac hypertrophy and the development of heart failure. These results indicate that PRMT5 is a possible molecular target for heart failure therapy.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Functional Analysis of GATA4 Complex, a Cardiac Hypertrophy-response Transcriptional Factor, Using a Proteomics Approach2016

    • Author(s)
      Sunagawa Y, Katanasaka Y, Wada H, Hasegawa K, Morimoto T.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 136 Issue: 2 Pages: 151-156

    • DOI

      10.1248/yakushi.15-00226-2

    • NAID

      130005121459

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2016-02-01
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secreted frizzled-related protein 5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury.2016

    • Author(s)
      Nakamura K, Sano S, Fuster JJ, Kikuchi R, Shimizu I, Ohshima K, Katanasaka Y, Ouchi N, Walsh K.
    • Journal Title

      J Biol Chem

      Volume: 291 Issue: 6 Pages: 2566-2575

    • DOI

      10.1074/jbc.m115.693937

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfunction (Stat-LVDF Study)2015

    • Author(s)
      Morimoto T, Katanasaka Y, Sunagawa Y, Hirano S, Miyazaki Y, Funamoto M, Hojo Y, Suzuki H, Morimoto E, Ueno M, Shimatsu A, Satoh-Asahara N, Yamakage H, Wada H, Hasegawa K.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 9 Pages: 1404-1409

    • DOI

      10.1248/bpb.b15-00126

    • NAID

      130005096994

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] PRMT5/MEP50 complex regulates p300/GATA4-induced cardiac hypertrophy2016

    • Author(s)
      Yusuke Miyazaki, Yasufumi Katanasaka, Yoichi Sunagawa, Hiromichi Wada, Koji Hasegawa and Tatsuya Morimoto
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protein Arginine Methyltransferase 5/Methylosome Protein 50 Complex Inhibits p300 Histone Acetyltransferase Activity and Hypertrophic Gene transcription in Cultured Cardiomyocytes2015

    • Author(s)
      Yusuke Miyazaki, Yasufumi Katanasaka, Yoichi Sunagawa, Hiromichi Wada, Koji Hasegawa and Tatsuya Morimoto
    • Organizer
      AHA Scientific Sessions 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PRMT5/MEP50メチル化複合体による心筋細胞肥大制御機構の解析2015

    • Author(s)
      刀坂泰史、中田淳也、宮崎雄輔、砂川陽一、鈴木秀敏、和田啓道、長谷川浩二、森本達也
    • Organizer
      第61回 日本薬学会東海支部大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] MEP50 RECRUITS PRMT5 TO p300 AND SUPRESSES p300/GATA4-INDUCED HYPERTROPHIC GENE TRANSCRIPTION2015

    • Author(s)
      Hiroki Wakabayashi, Yasufumi Katanasaka, Yusuke Miyazaki, Ryoga Sakurai, Yoichi Sunagawa, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    • Organizer
      Asian Pacific Society of Cardiology Congress 2015
    • Place of Presentation
      UAE, Abu Dhabi
    • Year and Date
      2015-04-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protein Arginine Methyltransferase 5 Inhibits cardiomyocyte Hypertrophy by methylating p300 in Cultured Cardiomyocytes2015

    • Author(s)
      Yuya Hojo, Yasufumi Katanasaka, Junya Nakada, Yoichi Sunagawa, Hidetoshi Suzuki, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
    • Organizer
      Asian Pacific Society of Cardiology Congress 2015
    • Place of Presentation
      UAE, Abu Dhabi
    • Year and Date
      2015-04-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PRMT5のメチル化活性がもたらす心肥大反応遺伝子転写抑制への影響2015

    • Author(s)
      若林弘樹、中田淳也、刀坂泰史、北條祐也、砂川陽一、鈴木秀敏、和田啓道、島津章、長谷川浩二、森本達也
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 心筋細胞内核内情報伝達機構の老性変化2015

    • Author(s)
      刀坂泰史
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 新規GATA4結合タンパク質MEP50の心肥大に対する機能解析2014

    • Author(s)
      櫻井涼賀、刀坂泰史、宮崎雄輔、中田淳也、砂川陽一、鈴木秀敏、和田啓道、長谷川浩二、森本達也
    • Organizer
      第5回 Molecular Cardiovascular Conference II
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 心肥大反応における新規GATA4結合タンパク質PRMT5の機能解析2014

    • Author(s)
      北條祐也、刀坂泰史、中川由紀子、宮崎雄輔、中田淳也、砂川陽一、鈴木秀敏、和田啓道、長谷川浩二、森本達也
    • Organizer
      第5回 Molecular Cardiovascular Conference II
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] アルギニンメチル化酵素PRMT5による心肥大反応抑制機構の解析2014

    • Author(s)
      中田淳也,刀坂泰史,砂川陽一,鈴木秀敏,宮崎雄輔,北條祐也,和田啓道,長谷川浩二,森本達也
    • Organizer
      第51回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 新規GATA4結合タンパク質PRMT5の機能解析2014

    • Author(s)
      刀坂 泰史, 中川 由紀子, 宮崎 雄輔, 中田 淳也, 砂川 陽一, 鈴木 秀敏, 和田 啓道, 長谷川 浩二, 森本 達也
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本大学薬学部
    • Related Report
      2013 Research-status Report
  • [Remarks] 静岡県立大学薬学部分子病態学分野

    • URL

      http://w3pharm.u-shizuoka-ken.ac.jp/byoutai/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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