Study on the role of protein arginine methyltransferase 5 in cardiac hypertrophy
Project/Area Number |
25860052
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | University of Shizuoka |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 心肥大 / 心不全 / アルギニンメチル化酵素 / 転写 / PRMT5 / MEP50 / p300/GATA4転写経路 / GATA4 / p300 / メチルトランスフェラーゼ |
Outline of Final Research Achievements |
Heart failure is one of the leading causes of death in industrialized countries, and cardiac hypertrophy is a risk factor for heart failure. We have demonstrated that PRMT5, a protein arginine methyltransferase, is involved in the promotion of cardiac hypertrophy and the development of heart failure. These results indicate that PRMT5 is a possible molecular target for heart failure therapy.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Effects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfunction (Stat-LVDF Study)2015
Author(s)
Morimoto T, Katanasaka Y, Sunagawa Y, Hirano S, Miyazaki Y, Funamoto M, Hojo Y, Suzuki H, Morimoto E, Ueno M, Shimatsu A, Satoh-Asahara N, Yamakage H, Wada H, Hasegawa K.
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 38
Issue: 9
Pages: 1404-1409
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
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