Elucidation of the molecular mechanism underlying neural stem cell differentiation regulated by a specific combination of glycans and their carrier proteins
| Project/Area Number |
25860053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
HIROKAZU Yagi 名古屋市立大学, 薬学研究科(研究院), 講師 (70565423)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖鎖修飾 / LewisX / HNK-1 / LewiｓX |
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| Outline of Final Research Achievements |
In this research project, we have focused on the system that the specific glycoproteins carry the specific glycans such as LewisX and HNK-1 carbohydrates, and attempted to elucidate the molecular mechanism underlying the definite glycosylation in neural stem cells. Furthermore, we have identified the molecule interacted with a specific glycan-possessing protein. The fact raises the possibility that a specific combination of glycans and their carrier proteins involved in the signaling pathways for the maintenance and differentiation of neural stem cells.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Stable isotope labeling of glycoprotein expressed in silkworms using immunoglobulin G as a test molecule2015
Author(s)
H.Yagi, M.Nakamura, J.Yokoyama, Y.Zhang, T.Yamaguchi, S.Kondo, J.Kobayashi, T.Kato, E.Y.Park, S.Nakazawa, N.Hashii, N.Kawasaki, and K.Kato
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Journal Title
J. Biomol. NMR
Volume: -
Issue: 2
Pages: 157-167
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] NMR-based structural validation of therapeutic antibody produced in Nicotiana benthamiana2015
Author(s)
H.Yagi, N.Fukuzawa, Y.Tasaka, K.Matsuo, Y.Zhang, T.Yamaguchi, S.Kondo, S.Nakazawa, N.Hashii, N.Kawasaki, T.Matsumura, and K.Kato
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Journal Title
Plant Cell Rep.
Volume: -
Issue: 6
Pages: 959-968
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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