Research Project
Grant-in-Aid for Young Scientists (B)
GPR55 is an orphan G protein-coupled receptor and a putative novel type of cannabinoid receptor. Its endogenous ligand is lysophosphatidylinositol (LPI). This study revealed that high levels of GPR55 mRNA were observed in the immune organs such as spleen and lymph nodes and the digestive organs such as small intestine and large intestine. The expression of GPR55 mRNA in the immune cells was next examined. High levels of GPR55 mRNA expression were observed in T and B cells. LPI enhanced the IgG secretion from B cell lines via a GPR55 dependent manner. It seems possible that GPR55 plays important physiological and/or pathophysiological roles in the function of the immune system.
All 2015 2014 2013
All Journal Article (4 results) (of which Peer Reviewed: 4 results, Open Access: 1 results) Presentation (11 results)
Biology (Basel)
Volume: 3 Issue: 4 Pages: 801-830
10.3390/biology3040801
J Biol Chem.
Volume: 289 Issue: 44 Pages: 30842-30856
10.1074/jbc.m114.574285
Prog Lipid Res.
Volume: 53 Pages: 18-81
10.1016/j.plipres.2013.10.001
Prostaglandins Other Lipid Mediat.
Volume: 107 Pages: 103-116
10.1016/j.prostaglandins.2013.05.004
