| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Pneumonia is a one of the major cause of death in influenza virus infectious disease. However, how influenza virus infection cause lung inflammation is largely unclear. We revealed mast cells that are usually cause allergic reaction, are also involved in lung inflammation by influenza virus infection. Mast cells sense the virus invasion and migrate into respiratory tract. Mast cells activate lung residential macrophages during influenza virus infection. After virus infection, mast cells express virus activation proteases and produce high infectious viruses. These mast cell’s behaviors exacerbate lung inflammation.
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