Elucidation of sPLA2 network as a regulator of metabolic inflammation
| Project/Area Number |
25860059
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
SATO Hiroyasu 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 (50546629)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 分泌性ホスホリパーゼ / メタボリックシンドローム / 慢性炎症 / 脂質代謝 / 分泌性ホスホリパーゼA2 |
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| Outline of Final Research Achievements |
To elucidate the role of secreted phospholipase A2 (sPLA2) in metabolic syndrome, we analyzed high fat diet-fed mice knockout mice for individual sPLA2 isoforms. We found that (1) sPLA2-IIE altered minor lipoprotein phospholipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE), and moderately facilitated lipid accumulation in adipose tissue and liver. (2) sPLA2-IID plays a role in amelioration of metabolic syndrome. (3) sPLA2-III facilitated recruitment of immune cells such as mast cells in adipose tissue. (4) sPLA2-X plays a role in amelioration of metabolic syndrome.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.2014
Author(s)
Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M.
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Journal Title
Cell Metab.
Volume: 20
Issue: 1
Pages: 119-132
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family.2014
Author(s)
Udagawa O, Ito C, Ogonuki N, Sato H, Lee S, Tripvanuntakul P, Ichi I, Uchida Y, Nishimura T, Murakami M, Ogura A, Inoue T, Toshimori K, Arai H.
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Journal Title
Genes Cells.
Volume: 19
Issue: 1
Pages: 13-27
DOI
Related Report
Peer Reviewed
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[Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.2013
Author(s)
Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
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Journal Title
J Exp Med.
Volume: 210
Issue: 6
Pages: 1217-1234
DOI
Related Report
Peer Reviewed
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[Presentation] Group X sPLA2 protects from colitis by mobilizing ω3 polyunsaturated fatty acid metabolites.2015
Author(s)
Murase, R., Taketomi, Y., Sato, H., Yamamoto, K., Tamamoto, T., Murakami, M.
Organizer
PLM2015
Place of Presentation
京王プラザホテル (東京)
Year and Date
2015-02-10 – 2015-02-12
Related Report
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[Presentation] Adipocyte-inducible group V and IIE sPLA2s play distinct roles in metabolic disorders.2015
Author(s)
Sato, H., Taketomi, Y., Yamamoto, K., Hara, S., Miyata, K., Oike, Y., Gelb, M.H., Murakami, M.
Organizer
PLM2015
Place of Presentation
京王プラザホテル (東京)
Year and Date
2015-02-10
Related Report
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[Presentation] Two secreted phospholipase A2 enzyme, PLA2G5 and PLA2G2E, are induced in hypertrophic adipocytes and distinctly regulate obesity.2013
Author(s)
Sato H, Taketomi Y, Ushida A, Yamamoto K, Gelb M. H, Murakami M.
Organizer
13h International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases
Place of Presentation
San Juan, Puerto Rico.
Related Report
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