| Project/Area Number |
25860060
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
DEYAMA Satoshi 北海道大学, 薬学研究科(研究院), 助教 (30634993)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | レゾルビンD1 / レゾルビンD2 / 抗うつ作用 / mTOR経路 / ω-3系脂肪酸 / DHA / リポポリサッカライド / PI3キナーゼ |
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| Outline of Final Research Achievements |
In the present study, we aimed to assess the effects of resolvin D1 (RvD1), an anti-inflammatory lipid mediator, on chronic pain-induced neuroinflammation and the negative affective states. Intracerebroventricular injections of RvD1 or resolvin D2 (RvD2) exerted antidepressant-like effects against lipopolysaccharide-induced depression-like behavior, a rodent model of inflammation-induced depression, via activation of mTOR signaling. Further investigations are required to verify whether RvD1 and RvD2 improve the negative affective states in a chronic pain model.
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