| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Since cardiomyocytes cease to proliferate immediately after birth, it has been believed that hearts have limited capacity of regeneration. Recently, several kinds of cardiac resident stem cells have been identified and much attention has been paid to their biological functions. So far, we revealed that that IL-6 family cytokines induce endothelial differentiation of cardiac Sca-1+ stem cells through STAT3/Pim-1 pathway. In this study, we have demonstrated that the myocardial expression of IL-27, a member of IL-6 cytokine family, is upregulated at chronic phase of myocardial infarction and myocarditis and that IL-27 functions as a novel regulator of the trans-differentiation of cardiac stem cells into endothelial cells through STAT3/Pim-1 pathway. We also explored the downstream targets of STAT3/Pim-1 pathway and identified a candidate substrate of Pim-1 kinase in cardiac stem cells.
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