Research Project
Grant-in-Aid for Young Scientists (B)
Insulin resistance on skeletal muscle cells contributes to the pathogenesis of type 2 diabetes. In this study, we examined the role of a disintegrin and metalloprotease ADAM17 on insulin signal transduction in L6 myotubes. Interluekin-1 increases ADAM17 expression through the ERK/NFκB and JNK/AP-1 signaling pathways. We also observed that endothelin-1 significantly inhibited insulin-induced IRS-1 tyrosine phosphorylation and Akt phosphorylation when ADAM17 were over-expressed. These results suggest that ADAM17 expression plays a pivotal role in ET-1-impaired insulin signal transduction in L6 myotubes.
All 2015 2014 Other
All Presentation (5 results)
