| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Statins inhibit HMG-CoA reductase which is the rate-limiting enzyme in the synthesis of cholesterol. Although statins are prescribed for many patients of hypercholesterolemia, there is a risk of rhabdomyolysis. We have shown that statins induce autophagy and cell death in human rhabdomyosarcoma cells. These effects were induced by unknown mTORC1 regulation pathway. In this study, it was suggested that control of cell cycle inhibit statin-induced cell death in rhabdomyosarcoma cells. This observations are expected to be applied to a reduction in statins side effects.
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