Functional coupling between calcium-sensing receptor and ion channel in pulmonary hypertension
| Project/Area Number |
25860068
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pharmacology in pharmacy
|
|---|
| Research Institution | Kinjo Gakuin University |
|---|
Principal Investigator |
YAMAMURA Aya 金城学院大学, 薬学部, 助教 (40633219)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 肺高血圧 / カルシウム感受性受容体 / イオンチャネル / 血管 / 肺動脈 / 平滑筋 / TRPチャネル / カルシウム / イメージング / 受容体 |
|---|
| Outline of Final Research Achievements |
Sustained vasoconstriction and vascular remodeling due to pulmonary arterial smooth muscle cell (PASMC) proliferation are key pathogenic events for idiopathic pulmonary arterial hypertension (IPAH). We have previously shown that calcium-sensing receptor (CaSR) is upregulated in IPAH-PASMCs and contributes to enhanced calcium response. In this study, we examined whether non-selective cation channel is involved in enhanced calcium influx followed by CaSR activation in IPAH-PASMCs. The expression levels of TRPC channel in IPAH-PASMCs were greater than in normal PASMCs. Knockdown of TRPC channel in IPAH-PASMCs with siRNA attenuated the CaSR-mediated calcium increase. In conclusion, the extracellular calcium-induced calcium increase due to functional coupling between CaSR and TRPC channel is a novel pathogenic mechanism contributing to the augmented calcium influx and excessive PASMC proliferation in IPAH patients.
|
Report
(3 results)
Research Products
(31 results)
-
[Journal Article] Notch Activation of Ca2+ Signaling Mediates Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension2015
Author(s)
Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX
-
Journal Title
Am J Respir Cell Mol Biol
Volume: in press
Issue: 3
Pages: 355-367
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Protective Effects of Fluvoxamine against Ischemia/Reperfusion Injury in Isolated, Perfused Guinea-Pig Hearts2014
Author(s)
T. Muto, H. Usuda, A. Yamamura, K. Yoshida, A. Ohashi, K. Mitsui-Saitoh, J. Sakai, Y. Sugimoto, H. Mizutani, T. Nonogaki, Y. Hotta
-
Journal Title
Biological and Pharmaceutical Bulletin
Volume: 37
Issue: 5
Pages: 731-739
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2.2013
Author(s)
Wan J, Yamamura A, Zimnicka AM, Voiriot G, Smith KA, Tang H, Ayon RJ, Choudhury MS, Ko EA, Wang J, Wang C, Makino A, Yuan JX.
-
Journal Title
Am J Physiol Lung Cell Mol Physiol.
Volume: 305(2)
Issue: 2
Pages: L154-L164
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension
Author(s)
Aya Yamamura, Qiang Guo, Hisao Yamamura, Adriana M. Zimnicka, Nicole M. Pohl, Kimberly A. Smith, Ruby A. Fernandez, Amy Zeifman, Ayako Makino, Hui Dong, Jason X.-J. Yuan
Organizer
IUPS2013
Place of Presentation
Birmingham, UK
Related Report
-
-
