A novel mechanism through regulation of tau phosphorylation and neuroprotective effect by drugs for the treatment of Alzheimer's disease
Project/Area Number |
25860069
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pharmacology in pharmacy
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Research Institution | Doshisha Women's College of Liberal Arts |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | アルツハイマー病 / ニューロン / 神経保護作用 / 薬理学 / ニコチン受容体 |
Outline of Final Research Achievements |
Donepezil is widely used as a therapeutic drug for Alzheimer's disease. It prevents cortical neurons against glutamate neurotoxicity through nicotinic acetylcholine receptors, followed by the phosphatidylinositol 3-kinase (PI3K)-Akt pathway. In cortical cultures, donepezil inhibited the activation of glycogen synthase kinase-3β(GSK-3β) through the PI3K-Akt pathway. Furthermore, downstream signaling of inhibition of GSK-3β activity involved the expression level of β-catenin and site-specific tau phosphorylation, rather than the expression level of Bcl-2.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Potential protective effect of highly bioavailable curcumin on an oxidative stress model induced by microinjection of sodium nitroprusside in mice brain.2014
Author(s)
Nazari, QA., Takada-Takatori, Y., Hashimoto, T., Imaizumi, A., Izumi, Y., Akaike, A., Kume, T.
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Journal Title
Food Funct.
Volume: 5
Issue: 5
Pages: 984-989
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Protective effect of serofendic acid, administered intravenously, on cerebral ischemia-reperfusion injury in rats.2013
Author(s)
Ioroi, T., Taguchi, K., Izumi, Y., Takada-Takatori, Y., Akaike, A., and Kume, T.
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Journal Title
Brain Res.
Volume: 1532
Pages: 99-105
DOI
Related Report
Peer Reviewed
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[Journal Article] Neuroprotective Effects of Curcumin and Highly Bioavailable Curcumin on Oxidative Stress Induced by Sodium Nitroprusside in Rat Striatal Cell Culture2013
Author(s)
Nazari, QA., Kume, T., Izuo, N., Takada-Takatori, Y., Imaizumi, A., Hashimoto, T., Izumi, Y., and Akaike, A.
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 36
Issue: 8
Pages: 1356-1362
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed
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[Journal Article] Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice2013
Author(s)
Nazari, QA., Kume, T., Takada-Takatori, Y., Izumi, Y., and Akaike, A.
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Journal Title
Journal of Pharmacological Sciences
Volume: 122
Issue: 2
Pages: 109-117
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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