drug discovery research targets for cosmetic compounds from unused plants
Project/Area Number |
25860078
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Natural medicines
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Research Institution | Hiroshima University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 糖化抑制活性 / メラニン産生抑制活性 / Ixora undulata / Linaria japonica / Ixora undurata / Syzygium samarangense / Centella asiatica / DPPHラジカル消去活性 / Syzygium grande |
Outline of Final Research Achievements |
Advanced glycation endproducts, which readily form and accumulate with sustained hyperglycemia, contribute to the development of diabetic complications and, as such, are considered a potential therapeutic target. Some isolated compounds from two plants showed strong inhibitory activity toward AGEs formation, the inhibitory activity of a positive control, aminoguanidine, being 2.48 mM. The current results ndicate that, in comparison with the reference compound, aminoguanidine, which once entered phase II clinical trials, but was withdrawn because of its side effects, flavonoid glycosides were clearly more efficient in inhibiting the formation of AGEs. Thus, these compounds seem to be worthy of consideration as potential therapeutic agents for diabetic complications and related diseases though additional biological evaluation.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] New cis-ent-clerodanes from Linaria japonica2015
Author(s)
Retno Widyowati, Sachiko Sugimoto, Yoshi Yamano, Sukardiman, Hideaki Otsuka, Katsuyoshi Matsunami
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Journal Title
Phytochemistry Letters
Volume: 14
Pages: 56-62
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Constituents of flowers of Paeoniaceae plants, Paeonia suffruticosa and Paeonia lactiflora2015
Author(s)
Ogawa, Keiko; Nakamura, Seikou; Sugimoto, Sachiko; Tsukioka, Junko; Hinomaru, Fusako; Nakashima, Souichi; Matsumoto, Takahiro; Ohta, Tomoe; Fujimoto, Katsuyoshi; Yoshikawa, Masayuki
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Journal Title
Phytochemistry Letters
Volume: 12
Pages: 98-104
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] メディシナルフラワー研究: ボタンおよびシャクヤク花部の抗酸化作用成分2015
Author(s)
小川 慶子, 中村 誠宏, 杉本 幸子, 月岡 淳子, 日丸 富紗子, 中嶋 総一, 松本 崇宏, 太田 智絵, 吉川 雅之, 松田 久司,
Organizer
日本薬学会 第135年会
Place of Presentation
兵庫医療大学 (兵庫)
Year and Date
2015-03-25 – 2015-03-28
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