| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We discovered a fungal strain Lsl3 from Lycopodium serratum var. longipetiolatum produced huperzine A, an anti-Alzheimer’s disease drug candidate from the traditional Chinese medicine Qian Ceng Ta (Huperzia serrata). The strain Lsl3 was classified to the genus Phoma based on molecular phylogenetic analysis. Also we isolated four new alkaloids, serralongamines A-D, from L. serratum var. longipetiolatum and elucidated their stuructures on the basis of spectroscopic data. Serralongamines B and D exhibited the inhibitory activity against foam cell formation in human macrophages, one of characteristic features of early atherosclerotic lesions.
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