Establishment of Amaryllidaceae alkaloid biosynthesis technology that was oriented to Alzheimer's drug discovery
| Project/Area Number |
25860081
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Natural medicines
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
ASANO TAKASHI 岩手医科大学, 薬学部, 助教 (10552888)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | ヒガンバナアルカロイド / 生合成 / 組織培養 / LCMS-IT-TOF / 薬用資源学 / LCMS-IT-TOF分析 / 次世代シークエンサー解析 / 毛状根 |
|---|
| Outline of Final Research Achievements |
Alzheimer's disease is a condition of unknown etiology; and since complete recovery is impossible, a number of medications aimed at slowing the progression of symptoms are under development, and the effectiveness of a number of alkaloids has been reported. This study was focused on a plant of the family Amaryllidaceae which contained galanthamine, a substance with an inhibitory effect on acetylcholinesterase; and the findings have allowed for establishing a stable and efficient production of Amaryllidaceae alkaloids in aseptically cultured plants, as a basis for the creation of effective therapeutic agents against Alzheimer's disease.
|
Report
(3 results)
Research Products
(2 results)
