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The research of intestinal metabolism experimental model built-in biological activity evaluation and liver protection substances from natural materials

Research Project

Project/Area Number 25860086
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Natural medicines
Research InstitutionFukuoka University

Principal Investigator

Tsuchihashi Ryota  福岡大学, 薬学部, 助教 (00369026)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords腸内細菌 / 薬物代謝 / 天然物 / 肝保護 / 代謝実験 / 成分分離 / 成分単離
Outline of Final Research Achievements

A lot of separating the glycosides from natural products that are likely to have hepatoprotective activity , was carried out metabolism studies using human-derived intestinal bacterial strain for those compounds .The compound obtained from their natural products , the evaluation of liver protective activity was carried out in terms of their metabolites .All glycoside isolated was found to undergo metabolism.By was carried out metabolism experiments using the 30 species of the human intestinal bacteria strain , it has also been found , such as each of the metabolic rate . As a result of the measurement of liver protective activity , significantly increased activity in the quercetin of the final metabolites of rutin and the eriodictyol of the final metabolites of eriocitrin was observed . Metabolism by intestinal bacteria has been suggested to affect the activation of activity .

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] ヒト腸内細菌株による代謝研究(11)食品中に含まれる各種フラボノイド類の代謝研究2015

    • Author(s)
      土橋良太、山本大貴、後藤直生、猪口智未、上野 菖、手島貴也、畑中真理子、中野大輔、金城順英
    • Organizer
      日本生薬学会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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