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Discovery of a stable equivalent of resolvins with potent anti-inflammatory action

Research Project

Project/Area Number 25860087
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Research InstitutionHokkaido University

Principal Investigator

FUKUDA HAYATO  北海道大学, 薬学研究科(研究院), 助教 (30434450)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsレゾルビン / 炎症 / 創薬 / 安定等価体 / 不飽和脂肪酸 / シクロプロパン / 全合成 / 天然物合成 / 脂質メディエーター / 構造活性相関 / エイコサペンタエン酸
Outline of Final Research Achievements

We achieved a total synthesis of resolvin E2 (RvE2) in short steps, and then succeeded to synthesize an analog of RvE2 (CP-RvE2), in which a chiral cis-cyclopropane moiety was introduced at the C11-C12 moiety. CP-RvE2 was more stable than RvE2 against oxidation and anti-inflammatory action of RvE2 was about the same as that of CP-RvE2. We succeeded to discover the stable equivalent of RvE2.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014

All Presentation (4 results) (of which Invited: 1 results)

  • [Presentation] Synthesis and SAR study of resolvin E22014

    • Author(s)
      Hayato Fukuda
    • Organizer
      DPhG Annual Meeting 2014
    • Place of Presentation
      Frankfurt
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] レゾルビンE2の安定化を指向した構造活性相関研究2014

    • Author(s)
      髙倉夕季
    • Organizer
      日本薬学会北海道支部 第141回例会
    • Place of Presentation
      札幌
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthesis and SAR study of resolvin E22014

    • Author(s)
      福田 隼
    • Organizer
      247th American Chemical Society National Meeting & Exposition
    • Place of Presentation
      Dallas Convention Center, Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] レゾルビンE2のシクロプロパン環導入による安定等価体の創製2014

    • Author(s)
      高倉 夕季
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学、熊本市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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