Discovery of a stable equivalent of resolvins with potent anti-inflammatory action

Research Project

Project/Area Number	25860087
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Drug development chemistry
Research Institution	Hokkaido University
Principal Investigator	FUKUDA HAYATO 北海道大学, 薬学研究科(研究院), 助教 (30434450)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	レゾルビン / 炎症 / 創薬 / 安定等価体 / 不飽和脂肪酸 / シクロプロパン / 全合成 / 天然物合成 / 脂質メディエーター / 構造活性相関 / エイコサペンタエン酸
Outline of Final Research Achievements	We achieved a total synthesis of resolvin E2 (RvE2) in short steps, and then succeeded to synthesize an analog of RvE2 (CP-RvE2), in which a chiral cis-cyclopropane moiety was introduced at the C11-C12 moiety. CP-RvE2 was more stable than RvE2 against oxidation and anti-inflammatory action of RvE2 was about the same as that of CP-RvE2. We succeeded to discover the stable equivalent of RvE2.

Report

(3 results)