Discovery of a stable equivalent of resolvins with potent anti-inflammatory action
| Project/Area Number |
25860087
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
FUKUDA HAYATO 北海道大学, 薬学研究科(研究院), 助教 (30434450)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | レゾルビン / 炎症 / 創薬 / 安定等価体 / 不飽和脂肪酸 / シクロプロパン / 全合成 / 天然物合成 / 脂質メディエーター / 構造活性相関 / エイコサペンタエン酸 |
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| Outline of Final Research Achievements |
We achieved a total synthesis of resolvin E2 (RvE2) in short steps, and then succeeded to synthesize an analog of RvE2 (CP-RvE2), in which a chiral cis-cyclopropane moiety was introduced at the C11-C12 moiety. CP-RvE2 was more stable than RvE2 against oxidation and anti-inflammatory action of RvE2 was about the same as that of CP-RvE2. We succeeded to discover the stable equivalent of RvE2.
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Report
(3 results)
Research Products
(4 results)
