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Investigation of the mechanism of alcohol withdrawal symptom with ethanol-injected mouse model

Research Project

Project/Area Number 25860098
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental and hygienic pharmacy
Research InstitutionJosai International University

Principal Investigator

ISHIBASHI Takuya  城西国際大学, 薬学部, 助手 (20555825)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsアルコール依存症 / 離脱症状 / 不安症 / うつ病 / エピジェネティクス
Outline of Final Research Achievements

Alcoholism is the common disorder. Although the medical treatment of alcoholism is to stop drinking an alcohol beverage, alcohol withdrawal symptom disrupt it. The purpose of this research is investigation of the mechanism of alcohol withdrawal symptom. In order to construct an animal model in which the symptom of alcoholism is assessed, we injected ethanol solution into mice chronically and observed the alcohol withdrawal behavior. Alcohol withdrawal behavior such as anxiety and depression was observed with several behavior test.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All Other

All Presentation (1 results)

  • [Presentation] イミプラミン長期投与による薬効発現の日内変動

    • Author(s)
      河合 洋、田中知佳、小平夏実、石橋拓也、光本篤史
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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