Investigation of thymic aging effect of environmental compounds via PPAR signal passway

• Project/Area Number: 25860102
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental and hygienic pharmacy
• Research Institution: Kinjo Gakuin University
• Principal Investigator: HIROMORI Youhei 金城学院大学, 薬学部, 助教 (60515956)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 胸腺 / DEHP / PFOA / PPARgamma / PPARγ / aP2

Outline of Final Research Achievements

We investigated the effect of environmental chemicals on thymic aging via PPAR gamma. di-(2-ethylhexyl)-phthalate (DEHP) administration in the C57BL/6 mice increased adipose and liver weight but had not changed thymus weight. perfluorooctanoic acid (PFOA) administration in the C57BL/6 mice decreased body, thymus and spleen weight, increased liver and adipose weight. Furthermore, DEHP and PFOA enhanced the mRNA levels of PPAR gamma and aP2 in the apipose and thymus. These results suggest that DEHP and PFOA promotes thymic aging via PPAR gamma.

Research Products

• [Journal Article] Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds. (2015)
  • Author(s): Harada, S., Hiromori, Y., Nakamura, S., Kawahara, K., Fukakusa, S., Maruno, T., Noda, M., Uchiyama, S., Fukui, K., Nishikawa, J., Nagase, H., Kobayashi, Y., Yoshida, T., Ohkubo, T., Nakanishi, T.,
  • Journal Title: Sci. Rep. Volume: 5:8520 Issue: 1 Pages: 1-7
  • DOI: 10.1038/srep08520
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Organotin compounds cause structure-dependent induction of progesterone in human choriocarcinoma Jar cells. (2015)
  • Author(s): Hiromori Y, Yui H, Nishikawa JI, Nagase H, Nakanishi T
  • Journal Title: The Journal of Steroid Biochemistry and Molecular Biology Volume: in press Pages: 190-198
  • DOI: 10.1016/j.jsbmb.2014.10.010
  • Peer Reviewed
• [Journal Article] A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding (2014)
  • Author(s): Gutierrez-Mazariegos J, Kumar Nadendla E, Lima D, Kane M, Nishikawa J, Hiromori Y, Nakanishi T, Santos MM, Castro LFC, Bourguet W, Schubert M, Laudet V
  • Journal Title: Endocrinology Volume: 155 Issue: 11 Pages: 4275-4286
  • DOI: 10.1210/en.2014-1181
  • Peer Reviewed
• [Presentation] トリフェニルスズの全身免疫系に対する加齢化促進作用の検討 (2014)
  • Author(s): 廣森 洋平、酒井 紀行、小林 亮、上代 大地、中西 剛、永瀬 久光
  • Organizer: 第21回日本免疫毒性学会学術年会
  • Place of Presentation: 徳島文理大学 国際会議場
  • Year and Date: 2014-09-11 – 2014-09-12
• [Presentation] 酵母 two-hybrid 法を用いたヒトおよびマウスPXRアゴニスト活性評価系の構築 (2014)
  • Author(s): 桑山 隼、廣森 洋平、西川 淳一、中西 剛、永瀬 久光
  • Organizer: 第41回 日本毒性学会学術年会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2014-07-02 – 2014-07-04
• [Presentation] 核内受容体を介した有機スズ化合物の毒性 (2014)
  • Author(s): 廣森洋平、中西剛、永瀬久光
  • Organizer: 第41回 日本毒性学会学術年会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2014-07-02 – 2014-07-04
  • Invited
• [Presentation] 核内受容体を介した有機スズ化合物の毒性 (2013)
  • Author(s): 廣森洋平、中西剛、永瀬久光
  • Organizer: メタルバイオサイエンス研究会2013
  • Place of Presentation: 静岡県立大学
  • Invited
• [Remarks] 金城学院大学学術研究データベース
  • URL: http://tdb.kinjo-u.ac.jp/search/index.php/search/teacher_info?id=185&s_tl_subject=71&rd=depart_list