Investigation of thymic aging effect of environmental compounds via PPAR signal passway
Project/Area Number |
25860102
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Environmental and hygienic pharmacy
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Research Institution | Kinjo Gakuin University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 胸腺 / DEHP / PFOA / PPARgamma / PPARγ / aP2 |
Outline of Final Research Achievements |
We investigated the effect of environmental chemicals on thymic aging via PPAR gamma. di-(2-ethylhexyl)-phthalate (DEHP) administration in the C57BL/6 mice increased adipose and liver weight but had not changed thymus weight. perfluorooctanoic acid (PFOA) administration in the C57BL/6 mice decreased body, thymus and spleen weight, increased liver and adipose weight. Furthermore, DEHP and PFOA enhanced the mRNA levels of PPAR gamma and aP2 in the apipose and thymus. These results suggest that DEHP and PFOA promotes thymic aging via PPAR gamma.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds.2015
Author(s)
Harada, S., Hiromori, Y., Nakamura, S., Kawahara, K., Fukakusa, S., Maruno, T., Noda, M., Uchiyama, S., Fukui, K., Nishikawa, J., Nagase, H., Kobayashi, Y., Yoshida, T., Ohkubo, T., Nakanishi, T.,
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Journal Title
Sci. Rep.
Volume: 5:8520
Issue: 1
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding2014
Author(s)
Gutierrez-Mazariegos J, Kumar Nadendla E, Lima D, Kane M, Nishikawa J, Hiromori Y, Nakanishi T, Santos MM, Castro LFC, Bourguet W, Schubert M, Laudet V
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Journal Title
Endocrinology
Volume: 155
Issue: 11
Pages: 4275-4286
DOI
Related Report
Peer Reviewed
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