| Project/Area Number |
25860103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 覚せい剤類似化合物 / 神経毒性 / プロテオミクス / バイオマーカー |
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| Outline of Final Research Achievements |
Little information is available on the basic toxicological properties of designer amphetamines. We evaluated relationship between the toxicity and their chemical structures of amphetamines substituted with flour and methoxy groups. In this study, we suggested that amphetamines have similar or larger ①cytotoxicity, ②inhibitory effect of neurite outgrowth, ③change the amount of monoamines in mouse brain and ④change the proteome in mouse brain compare to AP and MA treatment. In order to avoid abuse from amphetamines, it is necessary to development of laws for these analogs rapidly.
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