| Project/Area Number |
25860105
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Rimbara Emiko 国立感染症研究所, 細菌第二部, 主任研究官 (20349822)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ヘリコバクター / ヘリコバクター・シネディ / 薬剤耐性 / Helicobacter cinaedi / Helicobacter fennelliae |
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| Outline of Final Research Achievements |
Recently H. cinaedi infection has been increasingly reported.
We analyzed the mechanism of antimicrobial resistance in H. cinaedi, and identified the mutations conferring resistance to ciprofloxacin, clarithromycin, and b-lactams. Moreover the role of efflux pumps to the antimicrobial resistance in H. cinaedi was demonstrated. To elucidate the pathogenetic factors in enterohepatic Helicobacters, the genomes of H. fennelliae MRY12-0050, which is the first report for H. fennelliae, and H. cinaedi strain MRY08-1234 caused nosocomial infection , were analyzed. The suspected pathogenetic factors in H. cinaedi have been investigated to understand H. cinaedi pathogenicity.
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