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Pathogenicity and antimicrobial resistance in Enterohepatic Helicobacters

Research Project

Project/Area Number 25860105
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental and hygienic pharmacy
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Rimbara Emiko  国立感染症研究所, 細菌第二部, 主任研究官 (20349822)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsヘリコバクター / ヘリコバクター・シネディ / 薬剤耐性 / Helicobacter cinaedi / Helicobacter fennelliae
Outline of Final Research Achievements

Recently H. cinaedi infection has been increasingly reported.
We analyzed the mechanism of antimicrobial resistance in H. cinaedi, and identified the mutations conferring resistance to ciprofloxacin, clarithromycin, and b-lactams. Moreover the role of efflux pumps to the antimicrobial resistance in H. cinaedi was demonstrated. To elucidate the pathogenetic factors in enterohepatic Helicobacters, the genomes of H. fennelliae MRY12-0050, which is the first report for H. fennelliae, and H. cinaedi strain MRY08-1234 caused nosocomial infection , were analyzed. The suspected pathogenetic factors in H. cinaedi have been investigated to understand H. cinaedi pathogenicity.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2017 2015 2013

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Pararenal Lymphatic Cyst Infection Caused by <i>Helicobacter cinaedi</i>2015

    • Author(s)
      Akashi Y, Igarashi J, Suzuki H, Rimbara E, Shibayama K, Nin S, Tamai K, Yaguchi Y, Shiigai M, Oikawa T, Suzuki M.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 11 Pages: 1437-1440

    • DOI

      10.2169/internalmedicine.54.3991

    • NAID

      130005072934

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Other Helicobacters.2015

    • Author(s)
      Flahou B, Rimbara E, Mori S, Haesebrouck F, Shibayama K.
    • Journal Title

      Helicobacter.

      Volume: Sep;20 Suppl 1 Issue: S1 Pages: 62-7

    • DOI

      10.1111/hel.12259

    • Related Report
      2015 Research-status Report
    • Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] <i>Helicobacter cinaedi-</i>associated Vertebral Osteomyelitis in an Immunocompetent Patient2015

    • Author(s)
      Murata S, Suzuki H, Sakamoto S, Miki T, Rimbara E, Shibayama K, Koyama S, Tamai K, Yaguchi Y, Tada M.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 24 Pages: 3221-3224

    • DOI

      10.2169/internalmedicine.54.4574

    • NAID

      130005114261

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Improved allele-specific PCR assays for detection of clarithromycin and fluoroquinolone resistant of Helicobacter pylori in gastric biopsies: identification of N87I mutation in GyrA.2015

    • Author(s)
      Trespalacios AA, Rimbara E, Otero W, Reddy R, Graham DY.
    • Journal Title

      Diagn Microbiol Infect Dis

      Volume: Apr;81(4) Issue: 4 Pages: 251-5

    • DOI

      10.1016/j.diagmicrobio.2014.12.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Helicobacter cinaedi and H. fennelliae transmission in a hospital from 2008 to 2012.2013

    • Author(s)
      Rimbara E, Mori S, Kim H, Matsui M, Suzuki S, Takahashi S, Yamamoto S, Mukai M, Shibayama K.
    • Journal Title

      J Clin Microbiol

      Volume: in press Issue: 7 Pages: 2439-42

    • DOI

      10.1128/jcm.01035-13

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Draft Genome Sequence of Helicobacter fennelliae Strain MRY12-0050, Isolated from a Bacteremia Patient.2013

    • Author(s)
      Rimbara E, Matsui M, Mori S, Suzuki S, Suzuki M, Kim H, Sekizuka T, Kuroda M, Shibayama K.
    • Journal Title

      Genome Announc.

      Volume: Aug 8;1(4) Issue: 4

    • DOI

      10.1128/genomea.00512-13

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of γ-glutamyltranspeptidase in the pathogenesis of Helicobacter pylori infection.2013

    • Author(s)
      Rimbara E, Mori S, Kim H, Shibayama K.
    • Journal Title

      Microbiol Immunol.

      Volume: Oct;57(10) Issue: 10 Pages: 665-73

    • DOI

      10.1111/1348-0421.12089

    • NAID

      40019842403

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Mechanism of resistance to ceftriaxone in Helicobacter cinaedi2017

    • Author(s)
      Emiko Rimbara, Shigetarou Mori, Masato Suzuki, Kim Hyun, Keigo Shibayama
    • Organizer
      19th International Workshop on Campylobacter, Helicobacter and Related Organisms
    • Place of Presentation
      Nantes, France
    • Year and Date
      2017-09-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Helicobacter cinaediにおける薬剤排出ポンプと薬剤耐性との関連2017

    • Author(s)
      林原 絵美子,柴山 恵吾
    • Organizer
      第23回日本ヘリコバクター学会学術集会
    • Place of Presentation
      函館
    • Year and Date
      2017-06-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 動物濃厚接触患者の血液培養より分離されたHelicobacter trogontumの1症例2017

    • Author(s)
      采原 隆志, 鈴木 道雄, 今岡 浩一, 林原 絵美子, 柴山 恵吾
    • Organizer
      第28回日本臨床微生物学会
    • Place of Presentation
      長崎
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Helicobacter cinaediの分子疫学と薬剤耐性2015

    • Author(s)
      林原 絵美子,柴山 恵吾
    • Organizer
      第21回日本ヘリコバクター学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ピロリ菌 ー胃がんとの関連性と薬剤耐性についてー2015

    • Author(s)
      林原 絵美子
    • Organizer
      第6 回北里感染症教育フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2015-05-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] セフトリアキソン耐性Helicobacter cinaediにおけるペニシリン結合タンパク質変異2015

    • Author(s)
      林原 絵美子,森 茂太郎,金 玄,柴山 恵吾
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 同一の病院で分離されたH. cinaediとH. fennelliaeの分子疫学的解析と薬剤感受性2013

    • Author(s)
      林原 絵美子,森 茂太郎,金 玄,松井 真理,鈴木 里和,高橋 俊司,山本 聡,向井 正也 ,柴山 恵吾
    • Organizer
      第19回ヘリコバクター学会学術集会
    • Place of Presentation
      長崎
    • Related Report
      2013 Research-status Report
  • [Book] PCR Detection of Microbial Pathogens; PCR detection of Helicobacter pylori in clinical samples.2013

    • Author(s)
      Rimbara E, Sasatsu M, Graham DY.
    • Publisher
      Humana Press
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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