Pathogenicity and antimicrobial resistance in Enterohepatic Helicobacters
Project/Area Number |
25860105
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Environmental and hygienic pharmacy
|
Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
Rimbara Emiko 国立感染症研究所, 細菌第二部, 主任研究官 (20349822)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | ヘリコバクター / ヘリコバクター・シネディ / 薬剤耐性 / Helicobacter cinaedi / Helicobacter fennelliae |
Outline of Final Research Achievements |
Recently H. cinaedi infection has been increasingly reported. We analyzed the mechanism of antimicrobial resistance in H. cinaedi, and identified the mutations conferring resistance to ciprofloxacin, clarithromycin, and b-lactams. Moreover the role of efflux pumps to the antimicrobial resistance in H. cinaedi was demonstrated. To elucidate the pathogenetic factors in enterohepatic Helicobacters, the genomes of H. fennelliae MRY12-0050, which is the first report for H. fennelliae, and H. cinaedi strain MRY08-1234 caused nosocomial infection , were analyzed. The suspected pathogenetic factors in H. cinaedi have been investigated to understand H. cinaedi pathogenicity.
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Report
(5 results)
Research Products
(15 results)
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[Journal Article] Pararenal Lymphatic Cyst Infection Caused by <i>Helicobacter cinaedi</i>2015
Author(s)
Akashi Y, Igarashi J, Suzuki H, Rimbara E, Shibayama K, Nin S, Tamai K, Yaguchi Y, Shiigai M, Oikawa T, Suzuki M.
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Journal Title
Internal Medicine
Volume: 54
Issue: 11
Pages: 1437-1440
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The Other Helicobacters.2015
Author(s)
Flahou B, Rimbara E, Mori S, Haesebrouck F, Shibayama K.
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Journal Title
Helicobacter.
Volume: Sep;20 Suppl 1
Issue: S1
Pages: 62-7
DOI
Related Report
Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] <i>Helicobacter cinaedi-</i>associated Vertebral Osteomyelitis in an Immunocompetent Patient2015
Author(s)
Murata S, Suzuki H, Sakamoto S, Miki T, Rimbara E, Shibayama K, Koyama S, Tamai K, Yaguchi Y, Tada M.
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Journal Title
Internal Medicine
Volume: 54
Issue: 24
Pages: 3221-3224
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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