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Establishment of a method for the assessment of brain function measuring the expression level of ubiquitin ligase and its application for pharmacotherapeutics

Research Project

Project/Area Number 25860112
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionKyoto University

Principal Investigator

Omura Tomohiro  京都大学, 医学(系)研究科(研究院), 助教 (00439035)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords神経変性疾患 / HRD1 / SEL1L / ユビキチンリガーゼ / パーキンソン病 / 6-OHDA / 神経化学 / 小胞体ストレス
Outline of Final Research Achievements

It is very useful if we can objectively assess brain function through the measurement of marker proteins. I therefore analyze the function of ubiquitin ligase HRD1 and SEL1L, a HRD1 stabilizer, related to neurodegenerative diseases using Parkinson’s disease (PD) model cells.
We confirmed that the mRNA and protein levels of HRD1 or SEL1L are upregulated in the PD model, indicating that it is possible that these molecules might be disease markers in PD. Moreover, HRD1 and SEL1L coordinated to suppress neuronal cell death in PD model, suggesting that the HRD1-SEL1L complex may potentially be one of the novel therapeutic targets in PD.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015 2014 2013

All Presentation (3 results)

  • [Presentation] 6-OHDA誘発細胞死に対するユビキチンリガーゼHRD1の役割2015

    • Author(s)
      松田裕貴、大村友博、今井哲司、中川俊作、米澤淳、中川貴之、松原和夫
    • Organizer
      第65回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] オキシカム系NSAIDsはERストレス抑制を介してMPP+毒性を軽減する2014

    • Author(s)
      笹岡美和、大村友博、田崎嘉一、松田裕貴、小山智志、中川俊作、今井哲司、米澤淳、中川貴之、松原和夫
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会合同年会
    • Place of Presentation
      奈良県奈良市
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Mammalian target of rapamycin (mTOR) mediates neuroprotection by oxicam non-steroidal anti-inflammatory drugs against MPP+-induced SH-SY5Y cell death2013

    • Author(s)
      Tasaki Y, Ono T, Yamamoto J, Ohkubo T, Noda T, Omura T, Suno M, Matsubara K
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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