Critical role of MATE in renal dopamine secretion into tubular lumen
Project/Area Number |
25860114
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Kyushu University (2014) Kyoto University (2013) |
Principal Investigator |
KAJIWARA MOTO 九州大学, 医学(系)研究科(研究院), 助教 (70645506)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | トランスポーター / ナトリウム / MATE / ドパミン / 利尿 / 腎臓 / 体液量調節 / H+/有機カチオンアンチポーター |
Outline of Final Research Achievements |
The intrarenal dopaminergic system is likely responsible for regulating over 50% of net renal salt and water excretion when salt intake increases. Although dopamine synthesis is localized at proximal tubular cells, the molecular mechanism underlying dopamine secretion into urine remains unknown. We analyzed transport properties of dopamine by human and mouse multidrug and toxin extrusion (MATE) and measured urinary dopamine and sodium in wild-type and Mate1 null mice. Dopamine uptake by MATE exhibits saturable kinetics. The amount of urinary dopamine and sodium was decreased in Mate1 null mice. In conclusion, MATE plays a critical role in dopamine secretion into tubular lumen and promotes natriuresis.
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Report
(3 results)
Research Products
(5 results)