| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
In this study, we tried to clear the mechanism of immune responses by transcutaneous vaccination, whose efficacy is stronger than that of conventional injectable vaccination. We compared immune responses by transcutaneous vaccination using two type of transcutaneous vaccine devices (hydrogel patch and microneedle patch) to that by injectable vaccination (subcutaneously and intradermally). The differences between transcutaneous vaccination and injectable vaccination were recognized in mRNA expression in skin, population of dendritic cells in draining lymph nodes, and activation of T or B cells. Those results indicated that these differences contributed to high antibody production by transcutaneous vaccination.
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