To develop the personalized dosing system of neuropsychotropic drugs using population pharmacokinetic-pharmacodynamic approach

• Project/Area Number: 25860117
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: SARUWATARI Junji 熊本大学, 大学院生命科学研究部(薬), 准教授 (30543409)
• Co-Investigator(Renkei-kenkyūsha): FURUKORI Norio 弘前大学, 大学院医学研究科, 准教授 (20333734) ; ONIKI Kentaro 熊本大学, 大学院生命科学研究部(薬), 助教 (00613407)
• Research Collaborator: ISHITSU Takateru くまもと江津湖療育医療センター, えづこ小児神経発達診療センター, 診療センター長
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 個別医療 / 薬理ゲノム学 / 精神薬理学 / 神経薬理学 / 薬物動態－薬力学解析 / 薬物動態―薬力学 / 臨床精神神経薬理学 / モデリング&シミュレーション

Outline of Final Research Achievements

The present study conducted the clinical research to develop the personalized dosing system of neuropsychotropic drugs. Briefly, we investigated the pharmacokinetics and pharmacodynamics (including weight gain as an adverse reactions) of antiepileptic drug: clobazam, mood stabilizers: valproic acid and carbamazepine, antidepressant: paroxetine, antipsychotics: olanzapine, clozapine and risperidone, and we proposed the dosing regimen for these drugs based on the patient information, including genetic polymorphisms and the patient lifestyle.

Research Products

• [Journal Article] Safety analysis of zolpidem in elderly subjects 80 years of age or older: Adverse event monitoring in Japanese subjects. (2016)
  • Author(s): Kajiwara A, Yamamura M, Murase M, Koda H, Hirota S, Ishizuka T, Morita K, Oniki K, Saruwatari J & Nakagawa K.
  • Journal Title: Aging & mental health Volume: 印刷中 Issue: 6 Pages: 611-615
  • DOI: 10.1080/13607863.2015.1031640
  • Peer Reviewed / Open Access
• [Journal Article] Cytochrome P450 2C19 polymorphisms and valproic acid-induced weight gain. (2016)
  • Author(s): Noai M, Soraoka H, Kajiwara A, Tanamachi Y, Oniki K, Nakagawa K, Ishitsu T, Saruwatari J.
  • Journal Title: Acta Neurol. Scand. Volume: 133 Issue: 3 Pages: 216-223
  • DOI: 10.1111/ane.12473
  • Peer Reviewed
• [Journal Article] Helicobacter pylori-seropositivity along with pro-inflammatory interleukin-1 polymorphisms correlated with myocardial infarction. (2016)
  • Author(s): Tabata N, Hokimoto S, Akasaka T, Sueta D, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Yamabe H, Matsui K, Ogawa H.
  • Journal Title: Clinical trials and regulatory science in cardiology Volume: 17 Pages: 9-14
  • Peer Reviewed
• [Journal Article] The Influence of Phacoemulsification on Surgical Outcomes of Trabeculectomy with Mitomycin-C for Uveitic Glaucoma. (2016)
  • Author(s): Nishizawa A, Inoue T, Ohira S, Takahashi E, Saruwatari J, Iwao K, Tanihara H.
  • Journal Title: PLoS One Volume: 11 Issue: 3 Pages: e0151947-e0151947
  • DOI: 10.1371/journal.pone.0151947
  • Peer Reviewed / Open Access
• [Journal Article] Glutathione S-transferase K1 genotype and overweight status in schizophrenia patients: A pilot study. (2016)
  • Author(s): Oniki K, Kamihashi R, Tomita T, Ishioka M, Yoshimori Y, Osaki N, Tsuchimine S, Sugawara N, Kajiwara A, Morita K, Miyata K, Otake K, Nakagawa K, Ogata Y, Saruwatari J, Yasui-Furukori N.
  • Journal Title: Psychiatry Res. Volume: 239 Pages: 190-195
  • DOI: 10.1016/j.psychres.2016.03.025
  • Peer Reviewed / Open Access
• [Journal Article] Gender Differences in the Impact of CYP2C19 Polymorphisms and Low-Grade Inflammation on Coronary Microvascular Disorder. (2016)
  • Author(s): Akasaka T, Hokimoto S, Sueta D, Tabata N, Sakamoto K, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Ogawa H.
  • Journal Title: Am. J. Physiol. Heart Circ. Volume: - Issue: 11 Pages: H1494-H1500
  • DOI: 10.1152/ajpheart.00911.2015
  • Peer Reviewed
• [Journal Article] Helicobacter Pylori-seropositivity along with genetic and environmental factors predicts clinical outcome after acute coronary syndrome. (2016)
  • Author(s): Tabata N, Hokimoto S, Akasaka T, Sueta D, Arima Y, Sakamoto K, Yamamoto E, Izumiya Y, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogawa H.
  • Journal Title: Int J Cardiol. Volume: 212 Pages: 54-56
  • DOI: 10.1016/j.ijcard.2016.03.034
  • Peer Reviewed / Open Access
• [Journal Article] Influence of cytochrome P450 2D6 *10/*10 genotype on the pharmacokinetics of paroxetine in Japanese patients with major depressive disorder: A population pharmacokinetic analysis. (2016)
  • Author(s): Nishimura M, Ueda M, Saruwatari J, Nakashima H, Ogusu N, Aoki A, Tsuchimine S, Matsuda K, Iwashita K, Ono T, Oniki K, Shimoda K, Yasui-Furukori N.
  • Journal Title: Pharmacogenetics and Genomics Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis. (2015)
  • Author(s): Nakashima H, Oniki K, Nishimura M, Ogusu N, Shimomasuda M, Ono T, Matsuda K, Yasui-Furukori N, Nakagawa K, Ishitsu T, Saruwatari J.
  • Journal Title: PLoS One Volume: 10 Issue: 10 Pages: e0141266-e0141266
  • DOI: 10.1371/journal.pone.0141266
  • Peer Reviewed / Open Access
• [Journal Article] Higher risk of sulfonylurea-associated hypoglycemic symptoms in women with type 2 diabetes mellitus. (2015)
  • Author(s): Kajiwara A, Kita A, Saruwatari J, Oniki K, Morita K, Yamamura M, Murase M, Koda H, Hirota S, Ishizuka T, Nakagawa K.
  • Journal Title: Clin Drug Investig Volume: 35 Issue: 9 Pages: 593-600
  • DOI: 10.1007/s40261-015-0314-6
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Influence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects. (2015)
  • Author(s): Oniki K, Saruwatari J, Izuka T, Kajiwara A, Morita K, Sakata M, Otake K, Ogata Y, Nakagawa K.
  • Journal Title: PLoS ONE Volume: 10 Issue: 7 Pages: e0132640-e0132640
  • DOI: 10.1371/journal.pone.0132640
  • Peer Reviewed / Open Access
• [Journal Article] A functional variant in the γ-glutamyl transferase (GGT) 1 gene is associated with airflow obstruction in smokers. (2015)
  • Author(s): Morita K, Masuda N, Tanaka T, Saruwatari J, Oniki K, Kajiwara A, Otake K, Ogata Y, Nakagawa K.
  • Journal Title: Clin. Chem. Lab. Med. Volume: 53 Issue: 12
  • DOI: 10.1515/cclm-2015-0331
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between the aldehyde dehydrogenase 2*2 allele and smoking-related chronic airway obstruction in a Japanese general population: A pilot study. (2015)
  • Author(s): Morita K, Masuda N, Oniki K, Saruwatari J, Kajiwara A, Otake K, Ogata Y, Nakagawa K.
  • Journal Title: Toxicol. Lett. Volume: 236 Issue: 2 Pages: 117-122
  • DOI: 10.1016/j.toxlet.2015.05.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ABO Blood Type and Personality Traits in Healthy Japanese Subjects. (2015)
  • Author(s): Tsuchimine S, Saruwatari J, Kaneda A, Yasui-Furukori N.
  • Journal Title: PLoS One Volume: 10(5) Issue: 5 Pages: e0126983-e0126983
  • DOI: 10.1371/journal.pone.0126983
  • Peer Reviewed / Open Access
• [Journal Article] Interactive effects of a common γ-glutamyltransferase 1 variant and low high-density lipoprotein-cholesterol on diabetic macro- and micro-angiopathy. (2015)
  • Author(s): Jinnouchi H, Morita K, Takahiro T, Kajiwara A, Kawata Y, Oniki K, Saruwatari J, Nakagawa K, Otake K, Ogata Y, Yoshida A, Hokimoto S, Ogawa H.
  • Journal Title: Cardiovasc Diabetol Volume: 14 Issue: 1 Pages: 49-49
  • DOI: 10.1186/s12933-015-0212-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Possible association between moderate intellectual disability and weight gain in valproic acid-treated patients with epilepsy. (2015)
  • Author(s): Tanamachi Y, Saruwatari J, Noai M, Kamihashi R, Soraoka H, Yoshimori, Ogusu N, Oniki K, Yasui-Furukori N, Ishitsu T, Nakagawa K.
  • Journal Title: Neuropsychiatric disease and treatment Volume: 11 Pages: 1007-1014
  • DOI: 10.2147/ndt.s80898
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Possible association between moderate intellectual disability and weight gain in valproic acid–treated patients with epilepsy (2015)
  • Author(s): Tanamachi Y, Saruwatari J, Noai M, Kamihashi R, Soraoka H, Yoshimori Y, Ogusu N. Oniki K, Yasui-Furukori N, Ishitsu T, Nakagawa K.
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Associations between the common HNF1A gene variant p.I27L (rs1169288) and risk of type 2 diabetes mellitus are influenced by weight. (2015)
  • Author(s): Morita K, Saruwatari J, Tanaka T, Oniki K, Kajiwara A, Otake K, Ogata Y, Nakagawa K.
  • Journal Title: Diabetes & Metabolism Volume: 41 Issue: 1 Pages: 91-94
  • DOI: 10.1016/j.diabet.2014.04.009
  • Peer Reviewed
• [Journal Article] A case of repetitive and simultaneous stent thromboses. (2015)
  • Author(s): Sueta D, Hokimoto S, Enomoto K, Ono T, Tabata T, Kajiwara I, Kaikita K, Saruwatari J, Oniki K, Nakagawa K, Ogawa H.
  • Journal Title: International Journal of Cardiology Volume: 186 Pages: 210-212
  • DOI: 10.1016/j.ijcard.2015.03.217
  • Peer Reviewed
• [Journal Article] TDMの落とし穴～偽陽性と偽陰性～ (2015)
  • Author(s): 田口和明、猿渡淳二、平田憲史郎、丸山徹
  • Journal Title: 医療薬学 Volume: 41 Pages: 215-222
  • NAID: 130005144089
  • Peer Reviewed
• [Journal Article] Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis. (2014)
  • Author(s): Ogusu N, Saruwatari J, Nakashima H, Noai M, Nishimura M, Deguchi M, Oniki K, Yasui-Furukori N, Kaneko S, Ishitsu T, Nakagaswa K.
  • Journal Title: PLoS One Volume: 9 Issue: 11 Pages: e111066-e111066
  • DOI: 10.1371/journal.pone.0111066
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Possible impact of the CYP2D6*10 polymorphism on the nonlinear pharmacokinetic parameter estimates of paroxetine in Japanese patients with major depressive disorders. (2014)
  • Author(s): Saruwatari J, Nakashima H, Tsuchimine S, Nishimura M, Ogusu N, Yasui-Furukori N.
  • Journal Title: Pharmacogenomics and Personalized Medicine Volume: 7 Pages: 121-127
  • DOI: 10.2147/pgpm.s60747
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The effects of seijo-bofu-to, a traditional Japanese herbal medicine containing furanocoumarin derivatives, on the drug-metabolizing enzyme activities in healthy male volunteers. (2014)
  • Author(s): Saruwatari J, Takashima A, Yoshida K, Soraoka H, Ding TB, Uchiyashiki Y, Tsuda Y, Imamura M, Oniki K, Miyata K, Nakagawa K.
  • Journal Title: Basic Clin Pharmacol Toxicol Volume: - Issue: 4 Pages: 360-5
  • DOI: 10.1111/bcpt.12224
  • Peer Reviewed
• [Journal Article] A possible association of sex hormone-binding globulin with weight gain in the valproic acid-treated female patients with epilepsy. (2014)
  • Author(s): Saruwatari J, Uchiyashiki Y, Kajiwara A, Noai M, Tanamachi Y, Soraoka H, Deguchi M, Oniki K, Yasui-Furukori N, Kaneko S, Ishitsu T, Nakagawa K
  • Journal Title: International Journal of Clinical Pharmacology & Toxicology Volume: 3 Pages: 106-110
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Younger Females Are at Greater Risk of Vasodilation-Related Adverse Symptoms Caused by Dihydropyridine Calcium Channel Blockers: Results of a Study of 11,918 Japanese Patients (2014)
  • Author(s): A. Kajiwara, J. Saruwatari, (他 8名,最後)
  • Journal Title: Clin. Drug Investig. Volume: 34 Issue: 6 Pages: 431-435
  • DOI: 10.1007/s40261-014-0191-4
  • Peer Reviewed
• [Journal Article] Possible false-negative results on therapeutic drug monitoring of phenytoin using a particle enhanced turbidimetric inhibition immunoassay in a patient with a high level of IgM. (2014)
  • Author(s): Hirata K, Saruwatari J, Enoki Y, Iwata K, Urata Y, Aizawa K, Ueda K, Shirouzono T, Imamura M, Moriuchi H, Ishima Y, Kadowaki D, Watanabe H, Hirata S, Maruyama T, Fukunaga E.
  • Journal Title: Ther Drug Monit Volume: 36 Issue: 5 Pages: 553-555
  • DOI: 10.1097/ftd.0000000000000067
  • Peer Reviewed
• [Journal Article] Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethy-lclobazam in Japanese patients with epilepsy (2014)
  • Author(s): J. Saruwatari, Ogusu N, (他 11名)
  • Journal Title: Ther. Drug Monit. Volume: 36 Issue: 3 Pages: 302-309
  • DOI: 10.1097/ftd.0000000000000015
  • Peer Reviewed
• [Journal Article] Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients. (2014)
  • Author(s): Morita K, Miyazaki H, Saruwatari J, Oniki K, Kumagae N, Tanaka T, Kajiwara A, Otake K, Ogata Y, Arima Y, Hokimoto S, Ogawa H, Nakagawa K.
  • Journal Title: Toxicology Letters Volume: 232 Issue: 1 Pages: 221-225
  • DOI: 10.1016/j.toxlet.2014.11.014
  • Peer Reviewed
• [Journal Article] てんかん薬物療法実践のポイント臨床効果の評価を踏まえた視点から． (2014)
  • Author(s): 岩佐博人、猿渡淳二
  • Journal Title: 薬局 Volume: 65 Pages: 94-102
• [Journal Article] Possible impact of the cytochrome P450 2D6 polymorphism, CYP2D6*10, on the nonlinear pharmacokinetic parameter estimates of paroxetine in Japanese patients with major depressive disorders. (2014)
  • Author(s): Saruwatari J, Nakashima H, Tsuchimine S, Nishimura M, Ogusu N, Yasui-Furukori N.
  • Journal Title: Pharmagenomics and Personalized Medicine Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethylclobazam in Japanese patients with epilepsy. (2014)
  • Author(s): Saruwatari J, Ogusu N, Shimomasuda M, Nakashima H, Seo T, Tanikawa K, Tsuda Y, Nishimura M, Nagata R, Yasui-Furukori N, Kaneko S, Ishitsu T, Nakagawa K.
  • Journal Title: Therapeutic Drug Monitoring Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Gender differences in the incidence and progression of diabetic retinopathy among Japanese patients with type 2 diabetes mellitus: A clinic-based retrospective longitudinal study. (2014)
  • Author(s): Kajiwara A, Miyagawa H, Saruwatari J, Kita A, Sakata M, Kawata Y, Oniki K, Yoshida A, Jinnouchi H, Nakagawa K.
  • Journal Title: Diabetes Res Clin Pract Volume: - Issue: 3 Pages: e7-e10
  • DOI: 10.1016/j.diabres.2013.12.043
  • Peer Reviewed
• [Journal Article] Aldehyde dehydrogenase 2 as a potential protective factor for renal insufficiency in Japanese subjects with heart failure: A pilot study. (2014)
  • Author(s): Morita K, Oniki K, Miyazaki H, Saruwatari J, Ogata Y, Mizobe M, Yamamuro M, Hokimoto S, Ogawa H, Nakagawa K.
  • Journal Title: J Hum Hypertens Volume: 28 Issue: 4 Pages: 279-281
  • DOI: 10.1038/jhh.2013.90
  • Peer Reviewed
• [Journal Article] ABCC rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts. (2014)
  • Author(s): Sha'ari HM, Haerian BS, Baum L, Saruwatari J, Tan HJ, Rafia MH, Raymond AA, Kwan P, Ishitsu T, Nakagawa K, Lim SK, Mohamed Z.
  • Journal Title: Pharmacogenomics Volume: 15 Issue: 4 Pages: 459-466
  • DOI: 10.2217/pgs.13.239
  • Peer Reviewed
• [Journal Article] Meta-analysis: the effects of smoking on the disposition of two commonly used antipsychotic agents, olanzapine and clozapine. (2014)
  • Author(s): Tsuda Y, Saruwatari J, Yasui-Furukori N.
  • Journal Title: BMJ Open. Volume: 4 Issue: 3 Pages: e004216-e004216
  • DOI: 10.1136/bmjopen-2013-004216
  • Peer Reviewed
• [Journal Article] Absence of gargling affects topical adverse symptoms caused by inhaled corticosteroids in females. (2014)
  • Author(s): Kajiwara A, Kita A, Saruwatari J, Morita K, Oniki K, Yamamura M, Murase M, Koda H, Hirota S, Ishizuka T, Nakagawa K.
  • Journal Title: J Asthma Volume: 51 Issue: 2 Pages: 221-224
  • DOI: 10.3109/02770903.2013.857683
  • Peer Reviewed
• [Journal Article] Pregnane X receptor and hepatocyte nuclear factor 4alpha polymorphisms are cooperatively associated with carbamazepine autoinduction. (2014)
  • Author(s): Saruwatari J, Yoshida S, Tsuda Y, Okada Y, Ogusu N, Yoshida K, Oniki K, Yasui-Furukori N, Kaneko S, Ishitsu T, Nakagawa K.
  • Journal Title: Pharmacogenet Genomics Volume: 24 Issue: 3 Pages: 162-171
  • DOI: 10.1097/fpc.0000000000000030
  • Peer Reviewed
• [Journal Article] Gender difference in effect of cytochrome P450 2C19 polymorphism on the risk of diabetic retinopathy: a retrospective longitudinal study in Japanese patients with type 2 diabetes. (2013)
  • Author(s): Kajiwara A, Saruwatari J, Kita A, Kamihashi K, Miyagawa H, Sakata M, Noai M, Oniki K, Yoshida A, Jinnnouchi H, Nakagawa K.
  • Journal Title: Pharmacogenet Genomics Volume: 23 Issue: 12 Pages: 717-720
  • DOI: 10.1097/fpc.0000000000000009
  • Peer Reviewed
• [Journal Article] Possible associations between antioxidant enzyme polymorphisms and metabolic abnormalities in patients with schizophrenia. (2013)
  • Author(s): Saruwatari J, Yasui-Furukori N, Kamihashi R, Yoshimori Y, Oniki K, Tsuchimine S, Noai M, Sato Y, Nakagami T, Sugawara N, Saito M, Fujii A, Kajiwara A, Mihara S, Ogata Y, Kaneko S, Nakagawa K.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 9 Pages: 1683-1698
  • DOI: 10.2147/ndt.s52585
  • Peer Reviewed
• [Journal Article] The association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus. (2013)
  • Author(s): Morita K, Saruwatari J, Miyagawa H, Uchiyashiki Y, Oniki K, Sakata M, Kajiwra A,Yoshida A, Jinnouchi H, Nakagawa K.
  • Journal Title: Cardiovasc Diabetol Volume: 12 Issue: 1 Pages: 132-132
  • DOI: 10.1186/1475-2840-12-132
  • Peer Reviewed
• [Journal Article] Risk Factors for Adverse Symptoms During Dipeptidyl Peptidase-IV Inhibitor Therapy: A Questionnaire-Based Study Carried Out by the Japan Pharmaceutical Association Drug Event Monitoring Project in Kumamoto Prefecture. (2013)
  • Author(s): Kajiwara A, Saruwatari J, Sakata M, Morita K, Kita A, Oniki K, Yamamura M, Murase M, Koda H, Hirota S, Ishizuka T, Nakagawa K.
  • Journal Title: Drug Saf Volume: 36 Issue: 10 Pages: 981-987
  • DOI: 10.1007/s40264-013-0077-z
  • Peer Reviewed
• [Journal Article] 漢方薬と西洋薬の相互作用（チトクロムP450 に関して）．（総説） (2013)
  • Author(s): 猿渡淳二，空岡裕美，髙嶋綾佳．
  • Journal Title: 漢方と最新治療 Volume: 22 Pages: 287-291
• [Presentation] 抑肝散が薬物代謝酵素活性に及ぼす影響に関する臨床薬理学的検討 (2016)
  • Author(s): 空岡裕美、鬼木健太郎、松田和樹、小野達昌、内屋敷佳弘、上橋諒子、北愛矢菜、高嶋綾佳、門脇大介、宮田敬士、猿渡 淳二
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2016-03-26
• [Presentation] Disulfide-bond A oxidoreductase-like protein遺伝子変異と統合失調症患者の肥満との関係 (2016)
  • Author(s): 鬼木健太郎、大﨑夏海、上橋諒子、冨田哲、石岡雅道、土嶺章子、菅原典夫、大竹宏治、緒方康博、古郡規雄、猿渡淳二
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2016-03-26
• [Presentation] 抗てんかん薬の有効血中濃度域を再考する～病院―大学間の共同研究を通して～ (2016)
  • Author(s): 猿渡淳二
  • Organizer: 日本TDM学会 第50回セミナー
  • Place of Presentation: 熊本大学薬学部（熊本県）
  • Year and Date: 2016-02-13
  • Invited
• [Presentation] 核内受容体及びP450 oxidoreductaseの遺伝子多型を考慮したカルバマゼピンの母集団薬物動態解析 (2015)
  • Author(s): 松田和樹、猿渡淳二、津田義之、吉田志保、大楠直樹、吉田昂祐、今村元紀、小野達昌、鬼木健太郎、石津棟暎、中川和子
  • Organizer: 第36回日本臨床薬理学会学術総会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2015-12-09
• [Presentation] バルプロ酸を服用する若年てんかん患者の肥満に及ぼすCYP2C19遺伝子多型の検討 (2015)
  • Author(s): 猿渡淳二、野相まどか、空岡裕美、梶原彩文、棚町有紀子、鬼木健太郎、石津棟暎、中川和子
  • Organizer: 第36回日本臨床薬理学会学術総会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2015-12-09
• [Presentation] 非アルコール性脂肪性肝疾患予防のための非肥満者におけるPNPLA3遺伝子変異の意義 (2015)
  • Author(s): 鬼木健太郎，武藤奈瑠美，守田和憲，居塚智子，梶原彩文，坂田美咲，北愛矢菜，熊谷直樹，大竹宏治，緒方康博，中川和子，猿渡淳二
  • Organizer: 第25回日本医療薬学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2015-11-21
• [Presentation] 糖尿病における血管障害の性差に関する臨床的検討 (2015)
  • Author(s): 河田優希，梶原彩文，鬼木健太郎，北愛矢菜，坂本優季，大﨑夏海，宮川春奈，坂田美咲，守田和憲，猿渡淳二，吉田陽，井島廣子，宮本文夫，杉山正悟，稗島州雄，栗並昇，陣内冨男，梶原敬三，陣内秀昭，中川和子
  • Organizer: 第37回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 熊本大学薬学部（熊本県）
  • Year and Date: 2015-11-19
• [Presentation] 臨床応用を目指した基礎から臨床へのtranslational research ～遺伝情報に基づく精神神経疾患治療薬の個別化投与設計法の開発～ (2015)
  • Author(s): 猿渡淳二、石津棟暎、古郡規雄
  • Organizer: 第8回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 熊本大学薬学部（熊本県）
  • Year and Date: 2015-11-15 – 2015-11-16
  • Invited
• [Presentation] 小児てんかん患者のアドヒアランス・コンプライアンスを高めるための臨床薬理学的検討 (2015)
  • Author(s): 猿渡淳二，鬼木健太郎，石津棟暎
  • Organizer: 第42回日本小児臨床薬理学会学術集会
  • Place of Presentation: くまもと森都心プラザ（熊本県）
  • Year and Date: 2015-11-14
  • Invited
• [Presentation] 抗精神病薬に関する多剤併用の是非 薬物相互作用の観点から (2015)
  • Author(s): 猿渡淳二
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] Cytochrome P450 2D6遺伝子多型を考慮したパロキセチンの母集団薬物動態解析：第2報 (2015)
  • Author(s): 西村美紀, 上田幹人, 猿渡淳二, 中嶋洋生, 青木顕子, 大楠直樹, 松田和樹, 小野達昌, 岩下知磨, 土嶺章子, 下田和孝, 古郡規雄
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2015-10-29
• [Presentation] 抑肝散が健康成人男性の薬物代謝酵素活性に及ぼす影響 (2015)
  • Author(s): 空岡裕美, 松田和樹, 小野達昌, 内屋敷佳弘, 上橋諒子, 北愛矢菜, 高嶋綾佳, 鬼木健太郎, 門脇大介, 宮田敬士, 中川和子, 猿渡淳二
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Year and Date: 2015-10-29
• [Presentation] The impact of aldehyde dehydrogenase 2 polymorphism on the incidence and progression of lifestyle disease (2015)
  • Author(s): Kazunori Morita, Kentaro Oniki, Seiji Hokimoto, Junji Saruwatari, Akira Yoshida, Hideaki Jinnouchi, Koji Otake, Yasuhiro Ogata, Hisao Ogawa and Kazuko Nakagawa
  • Organizer: International Symposium on Chronic Inflammatory Diseases, Kumamoto
  • Place of Presentation: Oe Campus of Kumamoto University （Kumamoto Japan)
  • Year and Date: 2015-10-16
  • Int'l Joint Research
• [Presentation] Glutathione S-transferase K1遺伝子変異が肥満及び非アルコール性脂肪性肝疾患に及ぼす影響 (2015)
  • Author(s): 鬼木健太郎, 居塚智子, 守田和憲, 坂田美咲, 梶原彩文, 北愛矢菜, 熊谷直樹, 田中雄大, 河田優希, 猿渡淳二, 中川和子, 渡邊丈久, 吉田陽, 陣内秀昭, 大竹宏治, 緒方康博
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: シーモールホール（山口県）
  • Year and Date: 2015-05-21
• [Presentation] Hepatocyte nuclear factor-1A遺伝子変異と肥満が2型糖尿病に及ぼす影響 (2015)
  • Author(s): 守田和憲, 田中雄大, 益田菜月, 宮川春奈, 坂田美咲, 梶原彩文, 北愛矢菜, 河田優希, 鬼木健太郎, 猿渡淳二, 中川和子, 吉田陽, 陣内秀昭, 大竹宏治, 緒方康博
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: シーモールホール（山口県）
  • Year and Date: 2015-05-21
• [Presentation] 2型糖尿病患者の冠動脈疾患発症における性差の検討 (2015)
  • Author(s): 河田優希, 梶原彩文, 北愛矢菜, 坂本優季, 大﨑夏海, 宮川春奈, 坂田美咲, 守田和憲, 鬼木健太郎, 猿渡淳二, 中川和子, 吉田陽, 井島廣子, 宮本文夫, 杉山正悟, 稗島州雄, 栗並昇, 陣内冨男, 梶原敬三, 陣内秀昭
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: シーモールホール（山口県）
  • Year and Date: 2015-05-21
• [Presentation] KCNQ1遺伝子多型 (rs2237892) が2型糖尿病の臨床経過に及ぼす影響 (2015)
  • Author(s): 坂本優季, 鬼木健太郎, 梶原彩文, 河田優希, 守田和憲, 大﨑夏海, 益田菜月, 猿渡淳二, 中川和子, 吉田陽, 井島廣子, 宮本文夫, 杉山正悟, 稗島州雄, 栗並昇, 陣内冨男, 梶原敬三, 陣内秀昭
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: シーモールホール（山口県）
  • Year and Date: 2015-05-21
• [Presentation] γ-glutamyltransferase 1遺伝子多型と喫煙が慢性閉塞性肺疾患に及ぼす影響 (2015)
  • Author(s): 守田和憲、益田菜月、田中雄大、熊谷直樹、鬼木健太郎、猿渡淳二、大竹宏治、緒方康博、中川和子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館（和歌山県）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Aldehyde dehydrogenase 2遺伝子多型が慢性閉塞性肺疾患に及ぼす影響 (2015)
  • Author(s): 益田菜月、守田和憲、熊谷直樹、鬼木健太郎、猿渡淳二、大竹宏治、緒方康博、中川和子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館（和歌山県）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] gamma-glutamyltransferase 1遺伝子多型と喫煙が急性冠症候群に及ぼす影響 (2015)
  • Author(s): 田中雄大、守田和憲、鬼木健太郎、猿渡淳二、熊谷直樹、益田菜月、有馬勇一郎、掃本誠治、小川久雄、中川和子
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山県民文化会館（和歌山県）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 個別化投与設計を目指した抗てんかん薬バルプロ酸の治療効果に関する母集団薬物動態?薬力学解析 (2015)
  • Author(s): 中嶋洋生、猿渡淳二、大楠直樹、野相まどか、西村美紀、小野達昌、鬼木健太郎、石津棟暎、中川和子
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学（兵庫県）
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 精神科領域で薬物反応性（特に薬物動態）の個体差を決定する要因は何か？～個別化治療の実現を目指して～ (2015)
  • Author(s): 猿渡淳二
  • Organizer: 第3回熊本県病院薬剤師会精神科領域研究会
  • Place of Presentation: ネストホテル熊本（熊本県）
  • Year and Date: 2015-02-15
  • Invited
• [Presentation] Aldehyde dehydrogenase 2 遺伝子多型が生活習慣病に及ぼす影響～循環器疾患及び肺疾患に関する検討～ (2014)
  • Author(s): 守田和憲、鬼木健太郎、猿渡淳二、吉田陽、陣内秀昭、掃本誠治、小川久雄、大竹宏治、緒方康博、中川和子
  • Organizer: 第17回Aldh2ノックアウトマウス学会
  • Place of Presentation: アバンセ（佐賀県）
  • Year and Date: 2014-11-28
• [Presentation] CYP遺伝子多型のupdate：基礎から臨床応用まで (2014)
  • Author(s): 猿渡淳二
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会
  • Place of Presentation: 名古屋国際会議場（愛知県）
  • Year and Date: 2014-11-20 – 2014-11-22
  • Invited
• [Presentation] 知的障害がバルプロ酸服用患者の肥満に及ぼす影響 (2014)
  • Author(s): 棚町有紀子、猿渡淳二、野相まどか、大楠直樹、吉田志保、吉森友紀、出口真理子、上橋諒子、中嶋洋生、鬼木健太郎、古郡規雄、兼子直、石津棟暎、中川和子
  • Organizer: 第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会
  • Place of Presentation: 名古屋国際会議場（愛知県）
  • Year and Date: 2014-11-20 – 2014-11-22
• [Presentation] Female sex is an independent risk factor for diabetic microangiopathies in Japanese patients: Exploring possible mechanisms (2014)
  • Author(s): Kajiwara A, Kita A, Saruwatari J, Miyazaki H, Morita K, Oniki K, Yoshida A, Jinnouchi H, Nakagawa K.
  • Organizer: 7th International Symposium: Safety and Health in Agricultural and Rural Populations: Global Perspectives
  • Place of Presentation: Delta Bessborough Hotel (Saskatoon, Canada)
  • Year and Date: 2014-10-19 – 2014-10-22
• [Presentation] 薬剤の剤型別におけるpharmacokineticsの変化、 効果発現の相違に関して (2014)
  • Author(s): 猿渡淳二
  • Organizer: 第6回八戸てんかん治療会議
  • Place of Presentation: 八戸パークホテル（青森県）
  • Year and Date: 2014-07-23
  • Invited
• [Presentation] 肥満者の生活習慣病予防におけるβ3-adrenergic receptor遺伝子型の意義 (2014)
  • Author(s): 熊谷直樹、鬼木健太郎、守田和憲、宮崎裕子、益田菜月、大﨑夏海、猿渡淳二、大竹宏治、緒方康博、中川和子
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター（岡山県）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] γ-glutamyltransferase 1遺伝子多型が2型糖尿病患者の血管合併症に及ぼす影響 (2014)
  • Author(s): 田中雄大、守田和憲、河田優希、梶原彩文、北愛矢菜、鬼木健太郎、猿渡淳二、吉田陽、陣内秀昭、中川和子
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター（岡山県）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] Aldehyde dehydrogenase 2遺伝子多型が生活習慣病の発症・進展に及ぼす影響 (2014)
  • Author(s): 守田和憲、鬼木健太郎、猿渡淳二、吉田陽、陣内秀昭、掃本誠治、小川久雄、大竹宏治、緒方康博、中川和子
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター（岡山県）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] β3-adrenergic receptor遺伝子型の肥満及び肥満関連疾患予防における意義 (2014)
  • Author(s): 鬼木健太郎、熊谷直樹、守田和憲、梶原彩文、坂田美咲、北愛矢菜、宮崎裕子、居塚智子、河田優希、田中雄大、坂本優季、猿渡淳二、中川和子、 吉田陽、陣内秀昭、大竹宏治、緒方康博
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場（大阪府）
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Glutathione S-transferase K1遺伝子変異が冠動脈疾患患者の腎機能低下に及ぼす影響 (2014)
  • Author(s): 居塚智子、鬼木健太郎、守田和憲、宮崎裕子、梶原彩文、北愛矢菜、熊谷直樹、田中雄大、河田優希、猿渡淳二、中川和子、吉田陽、陣内秀昭、掃本誠治、小川久雄
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場（大阪府）
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Cytochrome P450 2C19遺伝子多型が糖尿病網膜症に及ぼす影響 (2014)
  • Author(s): 梶原彩文、北愛矢菜、上橋諒子、内屋敷佳弘、守田和憲、宮川春奈、坂田美咲、野相まどか、鬼木健太郎、猿渡淳二、中川和子、吉田陽、岩下薫子、井島廣子、宮本文夫、杉山正悟、稗島州雄、陣内冨男、梶原敬三、陣内秀昭
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場（大阪府）
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Pregnane X receptor遺伝子多型が健康成人とてんかん患者のcytochrome P450 3A活性に及ぼす影響 (2014)
  • Author(s): 今村元紀, 米満孝聖, 吉田昴祐, 津田義之, 鬼木健太郎, 猿渡淳二, 石津棟暎, 中川和子
  • Organizer: 日本薬学会第134回年会
  • Place of Presentation: 熊本大学黒髪キャンパス（熊本県）
• [Presentation] バルプロ酸服用患者における肥満と性ホルモン及び性ホルモン結合蛋白の関係 (2014)
  • Author(s): 内屋敷佳弘, 梶原彩文, 野相まどか, 空岡裕美, 大楠直樹, 鬼木健太郎, 猿渡淳二, 石津棟暎, 中川和子
  • Organizer: 日本薬学会第134回年会
  • Place of Presentation: 熊本大学黒髪キャンパス（熊本県）
• [Presentation] 喫煙がオランザピンとクロザピンの体内動態に与える影響に関するメタアナリシス (2013)
  • Author(s): 津田義之, 猿渡淳二, 西村美紀, 空岡裕美, 中川和子, 古郡規雄
  • Organizer: 第34回日本臨床薬理学会学術総会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] P-糖タンパク質を介した薬物相互作用 (2013)
  • Author(s): 猿渡淳二
  • Organizer: 第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会
  • Place of Presentation: 沖縄コンベンションセンター （沖縄県）
  • Invited
• [Presentation] 非定型抗精神病薬を服用する統合失調症患者における肥満及びメタボリックシンドロームに及ぼすCLOCK遺伝子多型の検討 (2013)
  • Author(s): 上橋諒子, 猿渡淳二, 古郡規雄, 佐藤靖, 中神卓, 斉藤まなぶ, 菅原典夫, 藤井学, 古郡 華子, 土嶺章子, 吉森友紀, 野相まどか, 梶原彩文, 今村元紀, 津田義之, 鬼木健太郎, 兼子直, 中川和子
  • Organizer: 第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会
  • Place of Presentation: 沖縄コンベンションセンター （沖縄県）
• [Presentation] 薬剤性うつ病のエビデンス (2013)
  • Author(s): 猿渡淳二
  • Organizer: 第10回日本うつ病学会総会
  • Place of Presentation: 西日本総合展示場AIMビル（福岡県）
  • Invited
• [Presentation] Cytochrome P450 2D6*10 遺伝子多型がパロキセチンの体内動態パラメータに及ぼす影響 (2013)
  • Author(s): 中嶋洋生, 猿渡淳二, 土嶺章子, 大楠直樹, 西村美紀, 古郡規雄
  • Organizer: 第30回日本TDM学会学術大会
  • Place of Presentation: 市民会館崇城大学ホール（熊本県）
• [Presentation] 遺伝子の個人差が薬効や副作用発現に及ぼす影響 (2013)
  • Author(s): 猿渡淳二
  • Organizer: 熊本県薬剤師会生涯学習研修会
  • Place of Presentation: 熊本県薬剤師会館（熊本県）
  • Invited
• [Presentation] 統合失調症患者における肥満及びメタボリックシンドロームに関わる遺伝子多型の検討 (2013)
  • Author(s): 猿渡淳二, 古郡規雄, 吉森友紀, 上橋諒子, 野相まどか, 梶原彩文, 今村元紀, 津田義之, 鬼木健太郎, 佐藤靖, 中神卓, 斉藤まなぶ, 菅原典夫, 藤井学, 古郡華子, 土嶺章子, 兼子直, 陣内秀昭, 三原修一, 緒方康博, 中川和子
  • Organizer: 第56回糖尿病学会年次学術集会
  • Place of Presentation: テトリア熊本ビル（熊本県）
• [Book] クロザピン100のQ&A－治療抵抗性への挑戦 (2014)
  • Author(s): 津田義之、猿渡淳二
  • Publisher: 星和書店
• [Remarks] 熊本大学生命科学研究部薬物治療学分野ホームページ
  • URL: http://www.pharm.kumamoto-u.ac.jp/Labs/tiryougaku/research/