| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, we investigated the feasibility of inhaled nucleic acid medicine (siRNA) formulation, notably siRNA loaded liposomes for pulmonary therapy using nebulization. The stabilities and inhaled characterization (aerodynamic particle sizes) of nebulized siRNA formulations were evaluated to evaluate the therapeutic potential of pulmonary siRNA using nebulizers. Furthermore, the behavior of surface-modified liposomes in the rat lung and whole body was monitored using a real-time in vivo imaging system. There results demonstrated that surface modification of liposomes using functional polymers achieved long-term residence time after pulmonary administration.
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