Development of pulmonary siRNA liposomes with long-term retention in the lung based on the evaluations of real-time in vivo imaging and inhalation properties
| Project/Area Number |
25860119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
Tahara Kohei 岐阜薬科大学, 薬学部, 講師 (30454325)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 吸入製剤 / siRNA / リポソーム / 肺局所 |
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| Outline of Final Research Achievements |
In this study, we investigated the feasibility of inhaled nucleic acid medicine (siRNA) formulation, notably siRNA loaded liposomes for pulmonary therapy using nebulization. The stabilities and inhaled characterization (aerodynamic particle sizes) of nebulized siRNA formulations were evaluated to evaluate the therapeutic potential of pulmonary siRNA using nebulizers. Furthermore, the behavior of surface-modified liposomes in the rat lung and whole body was monitored using a real-time in vivo imaging system. There results demonstrated that surface modification of liposomes using functional polymers achieved long-term residence time after pulmonary administration.
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Report
(4 results)
Research Products
(13 results)
