Role of membrane traffic in the development and maintenance of skeletal muscle.
Project/Area Number |
25860138
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General anatomy (including histology/embryology)
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Research Institution | Gunma University |
Principal Investigator |
Tajika Yuki 群馬大学, 医学(系)研究科(研究院), 講師 (90400738)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 骨格筋 / SNARE蛋白質 / 骨格筋細胞 / 小胞輸送 |
Outline of Final Research Achievements |
Skeletal muscle cells have long, cylindrical shape. Development of the skeletal muscle cells is thought to be regulated by the intracellular membrane traffic, however, the membrane trafficking system in skeletal muscle cells is not fully understood. To gain an insight, I generated the knock-out mice lacking a member of SNARE proteins. The heterozygote and homozygote mice were often died around the birth. Skeletal muscles in mice lacking the molecule of interest seem to be normal. I found morphological defect in respiratory system and nervous system. These findings suggest that a member of SNARE proteins function in the development of respiratory system and nervous system, but not in skeletal muscles.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] 顔面神経根周囲の三次元的解析2015
Author(s)
飯島圭哉、多鹿友喜、宮城島孝昭、依藤宏、好本裕平
Organizer
日本脳神経外科学会第74回学術総会
Place of Presentation
北海道札幌市、ロイトン札幌
Year and Date
2015-10-16
Related Report
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