| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Skeletal muscle cells have long, cylindrical shape. Development of the skeletal muscle cells is thought to be regulated by the intracellular membrane traffic, however, the membrane trafficking system in skeletal muscle cells is not fully understood. To gain an insight, I generated the knock-out mice lacking a member of SNARE proteins. The heterozygote and homozygote mice were often died around the birth. Skeletal muscles in mice lacking the molecule of interest seem to be normal. I found morphological defect in respiratory system and nervous system. These findings suggest that a member of SNARE proteins function in the development of respiratory system and nervous system, but not in skeletal muscles.
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